MyoD is a 3D genome structure organizer for muscle cell identity
2022年1月11日 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of...
Function of the myogenic regulatory factors Myf5, MyoD ... - PubMed
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.
Muscle regeneration controlled by a designated DNA dioxygenase
2021年5月25日 · Tet2 activates transcription of the key differentiation modulator Myogenin (MyoG) by actively demethylating its enhancer region. Re-expressing of MyoG in Tet2 KO myoblasts rescues the ...
MyoG基因结构与功能研究进展 - 百度学术
肌细胞生成素 (myogenin,MyoG)是生肌调节因子MRFs (MyoD,MyoG,Myf5和MRF4)家族的一员,它的表达具有控制成肌细胞融合的起始,促使成肌细胞的增殖作用,使单核成肌细胞转变成为多核的肌纤维.因此被认为在MyoD家族中具有中心地位.本文就MyoG基因的结构,定位,作用机制,多态性 ...
肌分化因子MyoD的研究进展 - 百度学术
肌分化因子MyoD (亦称MyoDI),是生肌调节因子 (myogenic regulatory factors,MRFs)家族四成员 (MyoD,MRF5,myoG,MRF4)之一,1987年首次被克隆.MyoD基因不仅可促使静止期的肌卫星细胞向成肌细胞转化,而且能把许多种类型细胞 (如成纤维细胞,脂肪细胞等)转化为成肌细胞,并可促进成肌 ...
Myogenin is required for assembly of the transcription machinery …
2021年1月19日 · We show here that MYOG is required for the recruitment of TBP and RNAPII to muscle gene promoters, indicating that MYOG is essential in assembling the transcription machinery. Genes regulated by MYOD1 and MYOG include genes required for muscle fusion, myomaker and myomerger, and we show that myomaker is fully dependent on …
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin …
2017年12月1日 · Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.
生肌调节因子及肌生成调控因素研究进展 - 百度学术
生肌调节因子（myogenic regulatory factors,MRFs）是调控肌肉生成的重要基因,家族中包括MyoD、MyoG、Myf5和Myf6。 MyoD能把多种类型细胞转化为成肌细胞,在肌肉特异基因转录调控中起着总开关作用;MyoG的表达能够控制成肌细胞融合的起始,促使成肌细胞增殖;Myf5协同MyoD在 …
在骨骼肌分化过程中，肌生成素是在肌肉基因上组装转录机制所必 …
Skeletal muscle gene expression is governed by the myogenic regulatory family (MRF) which includes MyoD (MYOD1) and myogenin (MYOG). MYOD1 and MYOG are known to regulate an overlapping set of muscle genes, but MYOD1 cannot compensate for the absence of …
The Myogenic Regulatory Factors, Determinants of Muscle …
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and ...