MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as …

2024年12月25日 · MYOD1 (Myogenic Differentiation 1) is a Protein Coding gene. Diseases associated with MYOD1 include Congenital Myopathy 17 and Myopathy, Centronuclear, 1. Among its related pathways are Signaling by TGFBR3 and Signaling by TGFB family members.

Low expression observed in reference dataset. 该基因编码的核蛋白属于转录因子的基本螺旋-环-螺旋家族和生肌因子亚家族。 它通过诱导细胞周期停滞来调节肌肉细胞分化，这是肌原性启动的先决条件。 该蛋白质还参与肌肉再生。 它激活自己的转录，可以稳定对肌生成的承诺。 [RefSeq 提供，2008 年 7 月] This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily.

MYOD1 is a positive diagnostic for biliary tract rhabdomyosarcoma. The expression of MyoD1 was more sensitive but less specific in patients with rhabdomyosarcoma. Myogenin and myogenic differentiation factor D (MyoD) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (myf)-5 mRNA increased in young only (P < 0.05).

Acts upstream of or within several processes, including myotube differentiation; regulation of RNA metabolic process; and skeletal muscle fiber adaptation. Located in euchromatin; myofibril; and nucleus. Part of transcription regulator complex.

2025年2月8日 · These results suggest a new mechanism by which MyoD1 function is coupled to NF-kappaB activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis. MyoD not only regulates terminal differentiation in muscle cells but also apoptosis through miRNA-mediated down-regulation of Pax3.

2025年1月4日 · Clinical resource with information about MYOD1, Myopathy, congenital, with diaphragmatic defects, respiratory insufficiency, and dysmorphic facies, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

15 小时之前 · To systematically assess the spatial positioning of MyoD1 and Pax7 in nuclei, we devised a pipeline for semi-automated image acquisition and analysis, by combining multi-location high-throughput ...

该基因编码一个核蛋白，属于基本螺旋-环-螺旋转录因子家族和肌源性因子亚家族。 它通过诱导细胞周期阻滞来调节肌肉细胞的分化，这是肌源性起始的先决条件。 这种蛋白质也参与肌肉再生。 它激活自己的转录，这可能稳定致力于肌发生。 [由RefSeq提供，2008年7月] [1] MYOD1是位于11号染色体的基因。

这个基因编码一个属于基本螺旋-环-螺旋家族转录因子和肌源因子亚家族的核蛋白。 它通过诱导细胞周期停滞来调节肌肉细胞分化，这是肌源性启动的前提。 该蛋白也参与肌肉再生。 它可以激活自己的转录，从而稳定肌生成素的承诺。 [由RefSeq，2008年7月提供] Dir./Indir. 该模块正在开发中，请耐心等待我们的数据更新。 Human MyoD: cDNA and deduced amino acid sequence. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal …