2024年12月25日 · MYOF (Myoferlin) is a Protein Coding gene. Diseases associated with MYOF include Angioedema, Hereditary, 7 and Hereditary Angioedema With Normal C1inh Not Related To F12 Or Plg Variant. Among its related pathways are Nuclear receptors meta-pathway and Signaling events mediated by VEGFR1 and VEGFR2.

Myoferlin is a protein that in humans is encoded by the MYOF gene. [5] [6] [7] [8] Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin.

Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes.

2025年2月9日 · Myoferlin is a key regulator of EGFR activity in breast cancer. Turtoi A, et al. Cancer Res, 2013 Sep 1. PMID 23864327. Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells. Blackstone BN, et al. Am J Physiol Cell Physiol, 2015 Apr 15. PMID 25631868.

2025年2月9日 · MYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells. These data provide the first evidence of myoferlin expression in solid human and mouse tumors.

Myoferlin（MYOF）是Ferlin蛋白家族的成员之一，能够广泛参与细胞迁移和侵袭的相关过程，包括膜泡运输、膜受体再循环和分泌蛋白外排等功能[3]。 肿瘤中MYOF过表达介导的膜泡运输导致细胞极性丧失、细胞生长信号失控、细胞粘附和细胞间的紧密连接减弱等，对于 ...

2019年11月19日 · Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing body of studies have identified MYOF as an oncogen …

2025年1月4日 · Clinical resource with information about MYOF, Angioedema, hereditary, 7, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2021年5月12日 · 在肝细胞癌中myof是维持egfr介导的信号通路的关键因子。人们最新发现myof是外泌体的成分之一，参与多项外泌体的生理功能过程。myof缺失可以抑制外泌体的融合，以及抑制外泌体运载货物至靶标细胞。

The protein encoded by this gene is a member of the ferlin family of proteins, which have been implicated in fusion events in muscle tissue. Members of this family have a carboxy-terminal single pass transmembrane domain and multiple C2 domains, which bind negatively charged Phospholipids in the presence of calcium ions.