MyRF is a transcription factor that promotes the expression of many genes important in the production of myelin. [7] It is therefore of critical importance in the development and maintenance of myelin sheaths. [8] The expression of MYRF is specific to …

2024年12月25日 · MYRF (Myelin Regulatory Factor) is a Protein Coding gene. Diseases associated with MYRF include Cardiac-Urogenital Syndrome and Encephalitis/Encephalopathy, Mild, With Reversible Myelin Vacuolization. Among its related pathways is Kallmann syndrome.

2022年11月10日 · MYRF-related cardiac urogenital syndrome (MYRF-CUGS) is primarily characterized by anomalies of the internal and external genitalia, congenital heart defects, and eye anomalies. 46,XY individuals can have a range of anomalies of the genitalia, from isolated unilateral cryptorchidism to ambiguous genitalia to typical-appearing female genitalia ...

Here we show that Myrf is a membrane-associated transcription factor that undergoes an activating proteolytic cleavage to separate its transmembrane domain-containing C-terminal region from a nuclear-targeted N-terminal region.

2025年1月4日 · Go to Variation Viewer for MYRF variants Summary This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation.

Myelin regulatory factor (MYRF) is a membrane-associated homo-trimeric protein that self-cleaves to release an N-terminal domain that activates transcription [27 – 29]. Myrf has a significant role in regulating the formation and maintenance of myelination in the central nervous system (CNS) both during development and in adulthood [30 – 32].

2021年4月17日 · The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates, representing a novel type of membrane-bound transcriptional factor (MBTF). In vertebrates, MYRF protein is required for myelin development and maintenance [1, 2].

2025年2月8日 · The results suggest that MYRF is a novel causative gene of 46,XY and 46,XX disorders of sex development and MYRF is a transcription factor regulating coelomic epithelium and/or coelomic epithelium derived cells proliferation and migration, which is essential for development of multiple organs.

MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases Neurosci Bull . 2021 Jun;37(6):881-884. doi: 10.1007/s12264-021-00678-9.

The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond …