2020年11月23日 · We found that pancreatic ductal adenocarcinomas (PDACs) overexpress the myelin regulatory factor (MYRF), an ER membrane-associated transcription factor (TF) released by self-cleavage. MYRF was expressed in the well-differentiated secretory cancer cells, but not in the poorly differentiated quasi-mesenchymal cells that coexist in the same tumor ...

Here we show that Myrf is a membrane-associated transcription factor that undergoes an activating proteolytic cleavage to separate its transmembrane domain-containing C-terminal region from a nuclear-targeted N-terminal region.

Expression of MYRF (C11orf9, MRF, Ndt80, pqn-47) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

2021年3月30日 · It makes it likely that one copy of a loss-of-function MYRF allele is sufficient to cause congenital anomalies. There are two ways for MYRF loss-of-function mutations to be pathogenic in a heterozygous state—haploinsufficiency and dominant negativity. Our sequential immunoprecipitation and DNA-binding and luciferase assays suggest that F387S ...

We found that pancreatic ductal adenocarcinomas (PDACs) overexpress the myelin regulatory factor (MYRF), an ER membrane-associated transcription factor (TF) released by self-cleavage. MYRF was expressed in the well-differentiated secretory cancer cells, but not in the poorly differentiated -mesenchymal cells that. coexist in the same tumor.

2024年12月25日 · MYRF (Myelin Regulatory Factor) is a Protein Coding gene. Diseases associated with MYRF include Cardiac-Urogenital Syndrome and Encephalitis/Encephalopathy, Mild, With Reversible Myelin Vacuolization. Among its related pathways is Kallmann syndrome.

2024年12月25日 · MYRF-AS1 (MYRF Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MYRF-AS1 include Autosomal Dominant Cerebellar Ataxia.

myrf - Explore an overview of myrf, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

Please include the following statement when referencing the CPTAC Assay Portal. We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

2020年11月23日 · We found that pancreatic ductal adenocarcinomas (PDACs) overexpress the myelin regulatory factor (MYRF), an ER membrane-associated transcription factor (TF) released by self-cleavage. MYRF was expressed in the well-differentiated secretory cancer cells, but not in the poorly differentiated quasi-mesenchymal cells that coexist in the same tumor.