2020年1月21日 · Myrf is a membrane-bound transcription factor that plays a key role in various biological processes. The Intramolecular Chaperone Auto-processing (ICA) domain of Myrf forms a homo-trimer,...

2024年12月25日 · MYRF (Myelin Regulatory Factor) is a Protein Coding gene. Diseases associated with MYRF include Cardiac-Urogenital Syndrome and Encephalitis/Encephalopathy, Mild, With Reversible Myelin Vacuolization. Among its related pathways is Kallmann syndrome.

MYRF, an unconventional transcription factor, begins embedded in the membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self-cleavage, allowing its N-terminal segment with an Ig-fold DNA-binding domain …

2017年4月24日 · The most prominent domain features for Myrf are an Ndt80-like DNA-binding domain and a chaperone of endosialidase domain. All members of the Myrf family show high sequence similarity for these two domains. Additionally, extensive evidence indicates that Myrf family proteins may bind to DNA.

2013年8月13日 · Here we show that Myrf is a membrane-associated transcription factor that undergoes an activating proteolytic cleavage to separate its transmembrane domain-containing C-terminal region from a nuclear-targeted N-terminal region.

2021年4月17日 · The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates, representing a novel type of membrane-bound transcriptional factor (MBTF). In vertebrates, MYRF protein is required for myelin development and maintenance [1, 2].

MYRF, an unconventional transcription factor, begins embedded in the membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self-cleavage, allowing its N-terminal segment with an Ig-fold DNA-binding domain …

该基因编码中枢神经系统髓鞘形成所需的转录因子，并可能调节少突胶质细胞分化。 它被认为通过增加影响髓磷脂生成的基因表达来发挥作用，但也可能直接促进髓磷脂基因表达。 小鼠模型中相似基因的缺失会导致严重的脱髓鞘。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 11 月] This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation.

Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, and synaptic plasticity. Upon autolytic cleavage, the Myrf N-terminal fragment enters the nucleus as a homo-trimer a …

2018年8月1日 · Followed by a self-cleavage by the intramolecular chaperone auto-processing (ICA) domain, DNA-binding domain (DBD) of MYRF is released from the endoplasmic reticulum (ER) and was then translocated to the nucleus to regulate gene expression. In present work, we have solved the crystal structure of the human MYRF-DBD to 1.85-Å resolution.