2013年10月31日 · We show that the transcription factor Myrf is directly activated by the transcription factor Sox10, and map a Sox10-responsive enhancer to an evolutionarily …

2020年2月20日 · Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 …

Our study identified Myrf as a decisive factor that helps Sox10 to switch between its target genes. Our analyses also revealed hitherto unknown and unexpected features of Myrf function. …

Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, …

2020年2月20日 · Sox10依赖性基因激活的抑制作用发生在缺少Myrf结合位点的基因上，并且可能涉及Myrf和Sox10之间的物理相互作用，然后进行螯合。 这两个相反的活动使Myrf将Sox10从 …

Our analysis highlights different mechanisms that establish cell type-specific genomic occupancy of Sox10, which reflects the unique characteristics of oligodendrocyte and Schwann cell …

2021年4月17日 · During OL development, SOX10 activates the expression of both OPC genes and differentiation-related genes. Once induced by SOX10 at the beginning of OL …

In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and …

2013年10月1日 · We show that the transcription factor Myrf is directly activated by the transcription factor Sox10, and map a Sox10-responsive enhancer to an evolutionarily …

2019年12月12日 · Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 …