Our study identified Myrf as a decisive factor that helps Sox10 to switch between its target genes. Our analyses also revealed hitherto unknown and unexpected features of Myrf function. Primary oligodendroglial cells were obtained from newborn Wistar rats of both sexes after growth in mixed glial cultures by shake-off (15).

Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation ...

2020年2月20日 · Sox10依赖性基因激活的抑制作用发生在缺少Myrf结合位点的基因上，并且可能涉及Myrf和Sox10之间的物理相互作用，然后进行螯合。 这两个相反的 EN

2020年2月20日 · Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 on genes that are essential during earlier phases of oligodendroglial development.

Myrf is not required for Sox10 and Olig2 localization and H3K27ac enrichment. One explanation for the unique distribution of Sox10 binding sites in spinal cord is that they are established in mature oligodendrocytes in concert with Myrf, which is induced in myelinating oligodendrocytes (Emery et al. 2009). To test this possibility, we ...

Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation ...

In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene.

2013年10月1日 · We show that the transcription factor Myrf is directly activated by the transcription factor Sox10, and map a Sox10-responsive enhancer to an evolutionarily conserved element in intron 1 of...

2013年10月31日 · Just as Sox10 directly regulates Krox20 in Schwann cells, they find it is also required for the induction of Myrf during terminal oligodendrocyte differentiation in vivo. This regulation by Sox10 was mapped to an enhancer in the first intron of the Myrf gene containing several Sox consensus motifs.

2019年12月12日 · Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 on genes that...