2014年6月1日 · N-myc is amplified in 15% to 20% of small-cell lung cancers and is associated with poor response to chemotherapy, rapid tumor growth, and shorter survival . N-myc …

2011年11月4日 · N-Myc is involved in the development of diverse tissues and organs during embryonic development, where it plays essential roles in regulating the cellular expansion and …

N-myc (MYCN), a member of the Myc family of basic-helix-loop-helix-zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well …

2020年4月28日 · Here, we describe the effects of N-Myc overexpression on metabolic reprogramming in neuroblastoma cells. Ectopic expression of N-Myc induced a glycolytic …

Myc: Master Regulator of Cell Cycle Entry and Proliferative Metabolism. The Myc proteins (c-Myc, L-Myc, S-Myc, and N-Myc) are a family of transcription factors that regulate growth and cell …

2018年2月4日 · Enhanced and deregulated expression of N-MYC, a member of the MYC family of transcription factors, drives the development of multiple tumors, including tumors of the …

Generally, myelocytomatosis oncogene (MYC) family oncogenes encode three highly interrelated nuclear phosphoproteins (MYC, MYCL, and MYCN) that are thought to function as sequence …

2008年12月4日 · In this paper, we show that c-myc and N-myc are coexpressed in the most immature hematopoietic stem-progenitor populations and provide genetic evidence that total …

5 天之前 · Since the N-Myc protein is predominantly located in the nucleus, the interaction between NPW and the N-Myc protein may require specific signal transduction pathways or …

In this review I summarize our understanding of the transcriptional activities of Myc family proteins and the roles of N-myc in morphogenesis, particularly as they relate to cellular proliferation …