N-acetylcysteine (NAC) has been used in clinical practice to treat critically ill septic patients, and more recently for COVID-19 patients. NAC has antioxidant, anti-inflammatory and immune-modulating characteristics that may prove beneficial in …

In this article, we review the pathogenesis of SARS-CoV-2 infection and the current knowledge of the mechanisms of action of NAC across disease stages. We also propose NAC posology strategies to manage COVID-19 patients in different clinical scenarios. Keywords: COVID-19, N-acetylcysteine, SARS-CoV-2, Antioxidant, Immunomodulation, Therapeutic role

We explored the potential benefits of the antioxidant, anti-inflammatory and anti-thrombotic drug N-acetylcysteine (NAC) administered orally in high doses (600 mg every 8 h), added to standard of care in COVID-19 patients by using the free text information contained in their electronic health records (EHRs).

2022年12月1日 · In this paper, we review the pathogenic features of SARS-CoV-2 and the current knowledge of the relevant mechanisms of action of NAC across the infection phases. We also propose potential NAC posology strategies to manage COVID-19 …

2024年2月15日 · The association between N-acetylcysteine (NAC) and COVID-19 remains undetermined; therefore, this meta-analysis assessed the clinical efficacy of NAC in the treatment of patients with COVID-19.

Based on a broad range of antioxidant and anti-inflammatory mechanisms, which are herein reviewed, the oral administration of NAC is likely to attenuate the risk of developing COVID-19, as it was previously demonstrated for influenza and influenza-like illnesses.

2023年6月30日 · Although the number of included studies was minimal, this meta-analysis suggests that NAC may have a positive effect on COVID-19 outcomes, specifically, a significant decrease in CRP and D-dimer levels and a significant increase in oxygen saturation, which decreased mortality.

The pharmacological activities of NAC and its effects on the mechanisms of disease progression make it a potential therapeutic agent for COVID-19. NAC is safe, tolerable, affordable, and easily available. Moreover, the antioxidant effects of the molecule may even prevent infection and play an important role as a complement to vaccination.

2021年4月12日 · In this study, we evaluate the efficacy of N-Acetylcysteine in patients with severe COVID-19. This is a prospective, randomized, single-blinded, phase 3 controlled clinical trial with two arms (ratio 1:1) parallel-group design of 40 patients, using the placebo in the control group.

2020年4月14日 · We therefore aimed to conduct a rapid review of NAC with specific emphasis on its potential for early administration in the community for patients at greater risk of severe COVID-19. NAC and its antioxidant properties. for GSH is increased, during oxidative stress.