Mechanisms of nucleus accumbens deep brain stimulation in …
2025年1月1日 · The nucleus accumbens (NAc), a frequent DBS target, has shown promise in treating psychiatric conditions like depression, obsessive-compulsive disorder, and addiction. …
摆脱抑郁，拥抱阳光！NAc-DBS疗法为抑郁症治疗提供新思路！
作者首先利用慢性不可预测轻度应激（CUMS）诱导小鼠抑郁，研究NAc-DBS的作用机制，发现NAc-DBS通过逆转CUMS诱导的背侧海马DG区高γ振荡降低、神经发生障碍以及小白蛋白阳性 …
Nucleus accumbens deep brain stimulation improves depressive …
2023年9月1日 · Our findings demonstrate that NAc-DBS can promote BDNF expression, which alters FC and metabolic profile in the dopaminergic pathway, suggesting a potential strategy …
Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain ...
2025年2月27日 · It is shown that NAc-DBS retrogradely activates mPFC neurons projecting to the NAc, and chemogenetic activation/inhibition of these DBS-activated neuron ensembles in the …
NAc-DBS corrects depression-like behaviors in CUMS mouse …
2024年2月15日 · Our results showed that NAc-DBS could disinhibit VTA-DA neurons by regulating the level of GABA and the activity of VTA-GABA in the VTA and could finally correct …
NAc-DBS corrects depression-like behaviors in CUMS mouse …
In this study, using the chronic unpredictable mild stress (CUMS) mouse model, we investigated the behavioral and neurobiological effects of NAc-DBS on the multidimensional depression …
The antidepressant effect of nucleus accumbens deep brain …
2022年11月1日 · Using the chronic unpredictable mild stress (CUMS) mouse model, we found NAc-DBS rescued depression-like behaviors, and reversed high gamma oscillation reduction …
Nucleus accumbens deep brain stimulation improves depressive …
2023年8月22日 · We found NAc-DBS restored emotional deficits in CSDS-subjected mice. Concurrent with behavioral amelioration, the CSDS DBS-on group exhibited enhanced FC in …
Bed Nucleus of the Stria Terminalis-Nucleus Accumbens Deep …
We conducted a deep brain stimulation (DBS) randomized controlled trial of the bed nucleus of the stria terminalis (BNST), an extended amygdala structure, and nucleus accumbens (NAc) in …
综述|脑深部电刺激治疗难治性抑郁障碍临床疗效及机制研究进展
2024年3月26日 · 重性抑郁障碍（major depressive disorder，MDD）是一种长期且具有致残性的严重精神障碍，有约三分之一的MDD患者经历药物治疗后仍缺乏反应，被定义为难治性抑郁 …