Probing the allosteric NBD-TMD crosstalk in the ABC ... - Nature
2024年1月5日 · Our data demonstrate that CH1 and CH2 undergo structural changes as part of the TMD-NBD cross-talk. A solid-state NMR study on the ABC transporter MsbA demonstrates …
Engineering of Norbornadiene/Quadricyclane Photoswitches for …
2020年7月14日 · The polycyclic strained molecule norbornadiene (NBD), which photoconverts to quadricyclane (QC), is of great interest because it has a high energy storage density and the …
Solid-State NMR Reveals Asymmetric ATP Hydrolysis in the …
2022年7月1日 · We use a combination of solid-state magic angle spinning (MAS) on the reconstituted transporter and soln. NMR on its isolated nucleotide binding domain (NBD) to …
Allosteric signal transmission in the nucleotide-binding domain ... - PNAS
2011年4月11日 · NMR titrations of the ADP-bound NBD with ATP revealed that binding affinities for ATP and ADP.Pi differ significantly for the 1–388 and 1–392 NBD constructs. By NMR, the …
A new approach exploiting thermally activated delayed …
2022年2月10日 · Molecular composites based on the TADF core phenoxazine–triphenyltriazine (PXZ-TRZ) anchored with norbornadiene (NBD) were synthesized, yielding compounds PZDN …
Synthesis, Optical Properties, and Antiproliferative Evaluation of NBD …
2022年12月21日 · These NBD-Aa-triterpene conjugates, in addition to being used as potential antiproliferative agents for cancer cells and having little cytotoxicity in nontumor cells, are …
Tunable Photoswitching in Norbornadiene (NBD)/Quadricyclane (QC ...
2021年7月30日 · Spatial distance has a major impact on the photoswitching in NBD/QC – fullerene hybrids. By careful molecular design and using MD simulations it was possible to …
A newly nitrobenzoxadiazole (NBD)-fused reversible fluorescence …
2021年6月1日 · NBD-pbz can offer a sensitive and selective tracking of pH changes from 3.2 to 7.6 with p Ka 5.51. NBD-pbz can visual pH in living cells and zebrafish as in vitro and in vivo …
通过固态 NMR 探测 ABC 转运蛋白 MsbA 中的变构 NBD-TMD 串 …
跨膜结构域中的底物结合与核苷酸结合结构域中的 ATP 结合和周转之间的变构相互作用必须通过 NBD/TMD 界面介导。 先前的研究表明，涉及两个称为耦合螺旋 1 和 2 (CH1、CH2) 的细胞内 …
1 H NMR spectra measured in CDCl 3 of: a) NBD before.
We report on a novel, inexpensive and effective process for the repeatable photoisomerization of norbornadiene (NBD) to its metastable isomer quadricyclane (QC), followed by catalytically …