The neural cell adhesion molecule NCAM1 appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis. Later in development, NCAM1 (CD56) expression is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle.

2024年12月25日 · NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include Rabies and Bile Duct Cancer . Among its related pathways are MAPK family signaling cascades and Nervous system development .

2019年5月23日 · Neural cell adhesion molecule 1 (NCAM1; CD56) is expressed in up to 20% of acute myeloid leukemia (AML) patients. NCAM1 is widely used as a marker of minimal residual disease; however, the biological function of NCAM1 in AML remains elusive.

Results provide direct evidence for NCAM1 as a susceptibility gene for schizophrenia, which offers support to a neurodevelopmental model and neuronal connectivity hypothesis in the onset of schizophrenia; results showed that NCAM1 might play an …

In this study, we found that NCAM regulated the proliferation, apoptosis, autophagy, migration, and epithelial-to-mesenchymal transition of human melanoma cells by determining the biological behavior of NCAM knockdown A375 and M102 human melanoma cells.

2025年1月4日 · neural cell adhesion molecule 1 provided by HGNC. HGNC:HGNC:7656. Ensembl:ENSG00000149294 MIM:116930; AllianceGenome:HGNC:7656. protein coding. REVIEWED. CD56; NCAM; MSK39. This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily.

2020年7月6日 · We found that olfactory conditioning in C. elegans induced ncam-1 expression and that loss of ncam-1 function selectively impaired associative long-term memory, without causing acquisition,...

2009年1月1日 · The mammalian neural cell adhesion molecule 1 (NCAM1) was the first cell adhesion molecule (CAM) to be identified (Jorgensen and Bock 1974, Rutishauser et al. 1976).

2017年1月3日 · One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression.

One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression.

2016年10月7日 · Rubinek et al. (2003) studied the role of pituicyte cell-cell contact mediated by CDH2 and NCAM1 in the regulation of GH secretion. RT-PCR showed CDH2 mRNA expression in 8 of 12 GH-secreting adenomas compared with 1 of 7 prolactin-cell adenomas.

Neural cell adhesion molecules 1 (NCAM1) and 2 (NCAM2) belong to the cell adhesion molecules of the immunoglobulin superfamily and have been shown to regulate formation, maturation, and maintenance of synapses.

NCAM1 is a prognostic marker in Glioblastoma multiforme, Pancreatic adenocarcinoma

neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc: 7656] CD56, MSK39, NCAM. Chromosome 11: 112,831,997-113,149,158 forward strand. GRCh37:CM000673.1. View alleles of this gene on alternative sequences. This gene has 30 transcripts (splice variants), 1 gene allele and 5 paralogues. Show transcript table.

Neural Cell Adhesion Molecule (NCAM) is a glycoprotein that plays a critical role in cell binding, migration, and differentiation. It is a member of the immunoglobulin supergene family and is modified post-translationally.

Building on earlier work that uncovered the evolutionary descent of the prion founder gene from an ancestral ZIP zinc transporter, we recently investigated a possible role of PrP C in a morphogenetic program referred to as epithelial-to-mesenchymal transition (EMT).

2019年5月23日 · Once expressed and activated on the surface of AML cells, NCAM1 activates the MAPK (MAP-kinase) signaling cascade to promote cell survival and proliferation, resistance to conventional AML chemotherapies, and leukemia stem cell function.

One of these markers, the Neural Cell Adhesion Molecule (NCAM) was first described in 1974 by Elizabeth Bock (Jacque et al. 1974) and designated as D2 antigen. Three years later, the group of Edelman (Thiery et al. 1977) approved that NCAM mediates cell–cell adhesion and established it as one of the first cell adhesion molecules.

According to bioinformatics analysis, NCAM1 was a target of miR-141-3p, which was confirmed by dual luciferase assay. We found that NCAM1 was significantly upregulated in AB tissues at the mRNA and protein levels. Furthermore, NCAM1 and E-cadherin were mainly expressed on the cell membrane of AB.

2024年11月5日 · CD56, also known as neural cell adhesion molecule 1 (NCAM1), is aberrantly expressed in 20% of AML patients (pts) (Sasca et. al. Blood 2019) and its presence on the surface of myeloblasts has been identified as an indicator of worse response to Venetoclax (VEN)-based therapy in newly diagnosed (ND) and relapsed or refractory (R/R) AML (Saultz ...