A topical preparation containing the R100E mutated form of the human recombinant nerve growth factor (NGF), with potential neuroprotective, neurotrophic and wound healing activities and …

Glossary. Study record managers: refer to the Data Element Definitions if submitting registration or results information.. Search for terms

CHF6467 is a mutated form of human recombinant nerve growth factor (NGF). The mutation selectively disrupts the binding of NGF to its p75NTR receptor while maintaining the affinity …

2020年9月20日 · We showed that the topical administration of CHF6467, a recombinant human NGF in which an amino acid substitution (R100E) abolished the hyperalgesic effect usually …

2022年4月20日 · CHF6467 is a recombinant mutated form of hNGF, with arginine replacing glutamine in position 100. This single point mutation selectively disrupts the binding of hNGF …

CHF6467 is a recombinant mutated form of hNGF, with arginine replacing glutamine in position 100. This single point mutation selectively disrupts the binding of hNGF to the p75NTR...

2023年2月24日 · CHF 6467 is a mutated form of the human Nerve Growth Factor (hNGF) being developed by Chiesi Farmaceutici for the treatment of diabetic foot ulcers.

Safety and Efficacy of Multiple Doses of the PAINLESS Nerve Growth Factor CHF6467 in Paediatric Subjects With Optic Pathway Glioma (OPG). A Randomized Clinical Trial (RCT) …

2025年3月20日 · CHF6467 is a recombinant modified form of human NGF devoid of algogenic activity (painless NGF). In rodent hippocampal slices exposed to oxygen and glucose …

chf-6467是由意大利凯西制药公司研发的一种重组细胞因子，是一种ngfr激动剂。 目前该药物最高研发阶段为临床二期，用于治疗糖尿病足溃疡。 CHF-6467-靶点: NGFR_适应症: 糖尿病足溃 …