DNA adductomics has been successfully used to identify and determine exogenous carcinogens that may contribute to the etiology of certain cancers, including bacterial genotoxins and an N …

2024年9月19日 · DNA adductomics has been successfully used to identify and determine exogenous carcinogens that may contribute to the etiology of certain cancers, including …

Poirier obtained her Ph.D. in 1977 while also working at the NIH, and shortly afterwards pioneered the use of immunoassays, with antisera specific for carcinogen-DNA adducts, for …

protonated and adduct species of sufficient intensity can provide distinctive information about the correct molecular mass. For compounds with high electron affinity, the electron capture …

2024年2月19日 · DNA adducts can form in critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to the onset of cancer. The detection …

The measurement of DNA adducts resulting from the exposure to a specific carcinogen can provide crucial information about the genotoxic potential of the chemical and its mechanism of …

Adductomics is a transformational biomedical research tool which utilizes “omics” approach to characterize and quantify exogenous and endogenous reactive compounds, to which the …

2019年11月18日 · DNA adducts occur at low abundance in humans, and current softwares do not reliably detect them when using common MS data acquisition methods. In this perspective, we …

DNA adducts analysis has the ability to provide this critical information. Methods to directly detect and quantify DNA adducts in humans have been developed in the past 30 years, with …

2014年3月17日 · Although triple quadrupole and ion trap mass spectrometry, particularly when using multistage scanning (LC-MS (n)), have shown promise in the field of DNA adductomics, …