NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established.

NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established. 1.

NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established ...

nci-n87是一种人胃癌细胞系，表现出上皮样形态，于1976年从一名男性胃癌患者的胃中（肝转移灶）分离。nci-n87细胞系为近二倍体，64%的受检细胞中存在双微体（dm）。据报道，nci-n87细胞的镀覆效率为4.3%。 nci-n87细胞具有以下特性和特征 分子特征

NCI-N87 cells express the surface glycoproteins carcinoembryonic antigen (CEA) and TAG 72, and are L-dopa decarboxylase (DDC) negative. They were minimally positive for vasoactive intestinal peptide (VIP) receptors and lacked gastrin receptors. They were found to express receptors for muscarinic cholinergic agents.

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

人胃癌细胞 NCI-N87 [N87]表达表面糖蛋白癌胚抗原（CEA）和 TAG 72，不变达 L-多巴脱羧酶（DDC）。 该细胞血管活性肠肽（VIP）受体活性极低，缺乏胃泌素. 受体。 它们表达毒蕈碱胆碱能剂的受体。 没有证据表明存在 N-myc，L-myc，myb 和 EGF受体基因的重组。 该细胞系表达的 c-myc 和 c-erb-B 2 RNA 水平与其他细胞系相当。 不表达以下基因：N-myc，L-myc，c-cis，IGF-2，或胃泌素释放肽。 据报道，NCI-N87 [N87]细胞的植板率率为 4.3％。 细胞名称：人胃癌 …

NCI-N87 [N87]是1976年从一名男性胃癌患者的胃中分离出来且具有上皮形态的细胞系。 NCI-N87细胞表达表面糖蛋白癌胚抗原 (CEA)和TAG 72, 且没有左旋多巴胺脱羧酶 (DDC)活性。 该细胞的血管活性的肠肽 (VIP)受体活性极低并缺乏胃泌激素受体。该细胞表达蕈毒碱胆碱受体。目前没有证据表明其存在N-myc, L-myc, myb和EGF受体基因的重组。 该细胞株表达的c-myc和c-erb-B 2 RNA水平与其它细胞株相当。 以下基因不表达: N-myc, L-myc, c-cis, IGF-2, 或胃泌激素释放 …

nci-n87细胞表达表面糖蛋白癌胚抗原(cea)和tag 72, 并且没有左旋多巴胺脱羧酶(ddc)活性。 它们的血管活性的肠肽(VIP)受体活性极低并缺乏胃泌激素受体。 它们表达蕈毒碱胆碱受体。没有证据表明存在N-myc, L-myc, myb和EGF受体基因的重组。

NCI-N87 是来源于人胃癌细胞，在 M-NSG 小鼠皮下接种后，能正常成瘤。 成瘤性验证完成. *使用本品系发表的文献需注明: NCI-N87 [N87] cell line (Cat. NO. NM-W02) was purchased from Shanghai Model Organisms Center, Inc.. Figure 2. Tumor growth curve of NCI-N87 xenograft model (n=4） Figure 3. Body weight change of NCI-N87 xenograft model (n=4） 野生型细胞株不进行出售服务，仅作为荷瘤鼠和体内药效进行服务。