2024年12月25日 · MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6) is a Protein Coding gene. Diseases associated with MT-ND6 include Leber Hereditary Optic Neuropathy, Modifier Of and Leber Optic Atrophy And Dystonia. Among its related pathways are Complex I biogenesis and Respiratory electron transport.

MT-ND6 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 6 protein (ND6). [5] The ND6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. [6]

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane.

Maternally inherited non-syndromic hearing loss is linked with a novel mitochondrial ND6 gene mutation. Reduced mitochondrial-encoded NADH dehydrogenase 6 gene expression drives inflammatory CD4[+]T cells in patients with systemic lupus erythematosus.

2021年7月19日 · 呼吸链复合物I亚基由核DNA和mtDNA共同编码，mtDNA编码的复合物I亚基ND1、ND2、ND3、ND4、ND4L、ND5、ND6都会发生突变导致Leber's Heredity Optic Neuropathy（成人视神经退行性疾病），MELAS，Leigh syndrome，MERRF（儿童神经退行性疾病）等恶性疾病。

2023年8月3日 · LHON-linked ND6 14484T > C (p.M64V) mutation caused complex I deficiency, diminished ATP production, increased production of reactive oxygen species (ROS), elevated apoptosis, and impaired mitophagy. Here, we investigated if the allotopic expression of human mitochondrial ND6 transgene corrected the mitochondrial dysfunctions due to LHON ...

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in brain; early conceptus; and secondary oocyte. Used to study Leber hereditary optic neuropathy and lactic acidosis.

2025年1月4日 · Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in brain; early conceptus; and secondary oocyte.

2021年6月18日 · mt-nd6基因(mitochondrialnadh-dehydrogenase6)由线粒体dna所编码，是构成线粒体电子传递链复合物ⅰ的亚基，在维持复合物ⅰ的正常活性和调控线粒体稳态中扮演了重要角色。mt-nd6的突变能够造成leber视神经病变和leigh综合征等线粒体遗传病的发生。

基因简介 中英文全称：NADH 脱氢酶亚基6 NADH dehydrogenase subunit 6 分布：线粒体|呼吸链复合体I (见于真核生物) 活性：NADH 脱氢酶 (辅酶Q)|氧化还原酶 参与：线粒体电子传 递, NADH 辅酶Q ... 对本文您有什么看法？ 2014-2025 © 360zhyx.com, All Rights Reserved. 转化医学网 版权所有. 基因简介 中英文全称：NADH 脱氢酶亚基6 NADH dehydrogenase subunit 6 分布：线粒体|呼吸链复合体I (见于真核生物) 活性：NADH 脱氢酶 (辅酶Q)|氧化还原酶 参与：线粒体电子传 …