MT-ND6 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 6 protein (ND6). [5] The ND6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. [6]

2024年12月25日 · MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6) is a Protein Coding gene. Diseases associated with MT-ND6 include Leber Hereditary Optic Neuropathy, Modifier Of and Leber Optic Atrophy And Dystonia. Among its related pathways are Complex I biogenesis and Respiratory electron transport.

Maternally inherited non-syndromic hearing loss is linked with a novel mitochondrial ND6 gene mutation. Reduced mitochondrial-encoded NADH dehydrogenase 6 gene expression drives inflammatory CD4[+]T cells in patients with systemic lupus erythematosus.

2025年2月8日 · Reduced mitochondrial-encoded NADH dehydrogenase 6 gene expression drives inflammatory CD4 (+)T cells in patients with systemic lupus erythematosus. Pediatric-onset dystonia associated with bilateral striatal necrosis and G14459A mutation in a …

Each of the MT-ND6 gene variants changes a single protein building block (amino acid) in the NADH dehydrogenase 6 protein. One common MT-ND6 gene variant is responsible for about 14 percent of all cases of Leber hereditary optic neuropathy, and it is the most common cause of this disorder among people of French Canadian descent. This genetic ...

2025年1月4日 · Title: Maternally inherited non-syndromic hearing loss is linked with a novel mitochondrial ND6 gene mutation. Reduced mitochondrial-encoded NADH dehydrogenase 6 gene expression drives inflammatory CD4[+]T cells in patients with systemic lupus erythematosus.

2010年1月27日 · Here we report our discovery that the ND6 gene and tRNA Glu were not lost but had been translocated to the control region (CR) from their canonical location between ND5 and cytochrome b genes. We characterized the CR and adjacent sequences of 22 notothenioid species representing all eight families of Notothenioidei to elucidate the mechanism ...

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane.

Recently, the mitochondrial (mt) NADH dehydrogenase subunit 6 (ND6) gene and the adjacent transfer RNA Glu (tRNA Glu ) were also reportedly lost. ND6 protein is crucial for the assembly and function of Complex I of the mt

2020年12月23日 · The MT-ND6 gene provides instructions for making a protein called NADH dehydrogenase 6. This protein is part of a large enzyme complex known as complex I, which is active in mitochondria. Mitochondria are structures within cells that convert the energy from food into a form that cells can use.