These 2-deoxy-D-glucose in poly (lactic-co-glycolic acid) nanoparticles not only amplified antitumor effects induced by sorafenib or anti–programmed death-1 antibody, but also suppressed anti–programmed death-1–resistant tumors. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world.

2021年12月6日 · Glucose and glutamine consumption are increased in mtDNA dysfunction, and so we targeted the use of both in cells carrying the pathogenic m.3243A>G variant with 2-Deoxy-D-glucose (2DG), or the...

2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。 * Please select Quantity before adding items. • Nature. 2025 Jan 15. [Abstract] • Signal Transduct Target Ther. 2023 Feb 15;8 (1):65. [Abstract] • Cell Res. 2021 Mar;31 (3):291-311. [Abstract] • Cancer …

2019年3月11日 · 2-Deoxyglucose (2-DG) is a glucose analog that inhibits glycolysis 9, 10. 2-DG can compete with glucose to bind hexokinase (the first rate-limiting enzyme of glycolysis) in cells and...

2002年9月23日 · To exploit nutrient deprivation as anti-cancer therapy, we investigated the effects of the anti-metabolite 2-deoxy-D-glucose on breast cancer cells in vitro. This compound has been shown to inhibit...

Results: The 2DG-PLGA-NPs induced cytotoxic effects and antitumor immunity through enhanced T-cell trafficking. In addition, 2DG-PLGA-NPs induced decreased lactate production and increased interferon-γ-positive T cells in liver tumors.

2012年2月15日 · The inhibitor of glycolysis and N-linked glycosylation, 2-deoxy-d-glucose (2DG), potently inhibited surface expression of MICA/B after histone

2-Deoxy-D-glucose (2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和 糖酵解抑制剂，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 磷酸葡萄糖异构酶 （将葡萄糖转化为 6-磷酸的酶）。 2-脱氧-D-葡萄糖 (16 mM) 在SK-BR-3细胞中诱导细胞凋亡，并在使用浓度为2时抑制在缺氧条件下培养的骨肉瘤细胞的生长。 储藏条件 ：储存温度2-8℃。 2-Deoxy-D-glucose (2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和糖酵解抑制剂，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 …

The ability of 2-deoxy- d -glucose (2-DG) to interfere with d -glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival.

2021年1月1日 · It is necessary to prove that the nanoparticle-mediated delivery of 2DG results in greater concentrations of 2DG in the tumor tissues than is realized by direct delivery of 2DG, regardless of the extremely low loading rate (8%) of 2DG into the 2DG-PLGA-NPs.