碳青霉烯耐药肠杆菌科 - 知乎 - 知乎专栏
碳青霉烯酶分为三组：Ambler A、B 和 D 类。最常见的 A 类碳青霉烯酶包括 KPC （肺炎克雷伯菌碳青霉烯酶）和 IMI（亚胺培南水解 β-内酰胺酶）。KPC 是所有 cpCRE 中最普遍的碳青霉烯酶基因。B 类由金属-β-内酰胺酶 (MBL) 结构定义。
Rapid emergence, transmission, and evolution of KPC and NDM
The emergence of Klebsiella pneumoniae carbapenemase (KPC) and New Delhi metallo-β-lactamase (NDM) coproducing CRKP (KPC-NDM-CRKP) further aggravates this issue. In this study, we identified 15 KPC-2-NDM-5-CRKPs as being responsible for an outbreak that involved 10 patients from October 2020 to May 2021.
Rapid emergence, transmission, and evolution of KPC and NDM …
In this study, we identified 15 KPC-2-NDM-5-CRKPs as being responsible for an outbreak that involved 10 patients from October 2020 to May 2021. The outbreak was sustained by ST11-KL47-OL101 KPC-2-NDM-5-CRKPs, which exhibited non-susceptible to all antimicrobials available in mainland China.
Carba NP 试验:是肠杆菌科细菌碳青霉烯酶的表型检测方法,简便快速,对检测KPC、NDM具有较好的敏感性(>90%)和特异性(>90%),但对OXA‐48 敏感性低,易漏检。
Rapid Identification of OXA-48-like, KPC, NDM, and VIM …
The OKNV assay is an accurate and rapid assay for identifying OXA-48-like, KPC, NDM, and VIM carbapenemases produced by Enterobacteriaceae isolates cultured on both SBA and the CHROMagar KPC media in the clinical microbiology laboratory.
Multispecies emergence of dual bla KPC/NDM carbapenemase …
2024年12月5日 · In this study, we report the multispecies emergence of dual CP-CRE co-harboring bla KPC and bla NDM (bla KPC/NDM) recovered as part of an ongoing prospective collection of invasive CRE from 11 healthcare centers in Chile and provide a detailed genomic characterization of these highly resistant pathogens.
KPC and NDM-1 Genes in Related Enterobacteriaceae Strains and …
2015年5月15日 · To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase.
【CRE network】同时产 NDM-1 和 KPC-2 酶的碳青霉烯耐药肺炎 …
2020年1月17日 · 全国 CRE 监测网络显示 2012 至 2016 年间主要的碳青霉烯酶类型有 KPC-2（76.5%）和 NDM-1（9.3%）。 KPC-2 和 NDM-1 都可水解绝大多数β-内酰胺药物，包括碳青霉烯类；不同之处在于 KPC-2 为丝氨酸酶，水解氨曲南，能被新型酶抑制剂阿维巴坦所抑制，而 NDM 为金属酶，不水解氨曲南，不被阿维巴坦、韦博巴坦等抑制。 携带 KPC-2 和 NDM-1 的 CRKP（KPC-2-NDM-1-CRKP）具有更高水平的耐药性，且对新上市的头孢他啶/阿维巴坦耐药 …
产NDM-1和产KPC-2耐碳青霉烯类肺炎克雷伯菌临床及分子流行病 …
2024年6月22日 · 中国细菌耐药监测网（CHINET）监测数据显示，肺炎克雷伯菌（KP）对亚胺培南和美罗培南的耐药率分别从2005年的3.0%、2.9%上升至2018年的25.5%、26.3%，2019—2021年的耐药率呈下降趋势，但其检出率仍超过23%。 根据中国儿童细菌耐药监测组（ISPED）的监测结果，儿童分离的KP对美罗培南的耐药率由2016年的13.4%上升至2020年的23%，并且在不同年龄组中新生儿患者碳青霉烯类肠杆菌目细菌（CRE）感染比例最高。 …
The transferability and evolution of NDM-1 and KPC-2 co …
2019年8月13日 · Plasmid transferability assay and phylogenic analysis suggested an evolutionary pathway that KPC-2-NDM-1-CRKP emerged from a KPC-2-CRKP progenitor which acquired another highly transferable blaNDM-1 plasmid later. Further, demographics and stability test revealed that these isolates were stable and had the potential for transmission among patients.