Adenosine 2A receptor and TIM3 suppress cytolytic killing of …
2022年1月10日 · Edmunds et al. examine how the adenosine receptor A2AR and the checkpoint molecule TIM3 suppress the killing of Renca tumors expressing hemagglutinin (HA) as a …
Impact of the selective A2AR and A2BR dual antagonist AB928
2022年10月20日 · NECA-mediated drifting of this phenotype was blocked by AB928 (Figs. 3c and S2b). Activation-induced upregulation of the inhibitory receptors PD-1 and TIM3 was inhibited …
Frontiers | Simultaneous targeting of Tim3 and A2a receptors …
2024年5月23日 · In this study, we evaluated the impact of genetic targeting of Tim3 and A2a receptors on the antitumor function of human mesothelin-specific CAR T cells (MSLN-CAR) in …
TIM-3靶点科普_机制原理&研究进展 - 知乎 - 知乎专栏
TIM-3（T细胞免疫球蛋白粘蛋白-3，又称 CD366 、HAVCR2）是一种 负调控的免疫检查点蛋白。 表达于CD4+T细胞亚群（Th1/Th17细胞）调节性T细胞 (Tregs)、 CD8+T细胞 亚群 (Tc1)以及 …
火热的免疫检查点——TIM3靶点 - 知乎 - 知乎专栏
TIM-3（T cell immunoglobulin domain and mucin domain-3） T 淋巴细胞免疫球蛋白黏蛋白 3，是一种活化诱导的抑制性分子，参与慢性病毒感染和癌症的免疫耐受和 T 细胞衰竭。 通过与 …
TIM-3 restrains anti-tumour immunity by regulating inflammasome ...
T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a molecule expressed on interferon-γ producing T cells 1, is emerging as an important immune-checkpoint …
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
2014年10月26日 · T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to …
New emerging targets in cancer immunotherapy: the role of TIM3
2019年1月1日 · TIM3 is upregulated on PD-1 antibody (Ab)-bound TILs in mice with lung cancers that initially responded to PD-1 blockade, then progressed. The addition of an anti-TIM3 Ab …
TIM-3是T细胞耗竭的标志物，靶向TIM-3可恢复T细胞抗癌活力
2021年8月1日 · 该研究发现，T细胞表面的一种关键蛋白质Tim-3可作为T细胞耗竭的标志物，更重要的是，Tim-3还可以作为恢复T细胞活力的治疗靶点，通过药物靶向Tim-3能够重新恢复T细 …
Adenosine 2A receptor and TIM3 suppress cytolytic killing of …
2022年1月10日 · Edmunds et al. examine how the adenosine receptor A 2A R and the checkpoint molecule TIM3 suppress the killing of Renca tumors expressing hemagglutinin (HA) as a …