2024年12月25日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.

2020年3月28日 · 在所有E3连接酶中，它们的开启开关（on-switch）中的大约三分之一是一种类似于泛素的小蛋白，即NEDD8。 NEDD8控制对其他蛋白的关闭

拟素化修饰（Neddylation） 是近年来发现的新型蛋白质翻译后修饰，可以广泛地调节生物学过程，如细胞周期、信号传导和免疫识别等。 泛素样蛋白 NEDD8 通过类似泛素化的过程与目标蛋白结合。 NEDD8和泛素的序列有59%的相同性。 目前研究最好的拟素化底物来自最大的泛素E3连接酶家族 cullin-RING连接酶 （CRLs），它们通过C端构象变化激活。 那么影响拟素化过程的工具酶、底物有哪些呢？ 拟素化有什么功能？ 国自然标书如何蹭到这个新前沿？ 今天小编就带大家一 …

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a …

NEDD8（neural precursor cell expressed, developmentally downregulated 8）最初在脑中发现，但后来证明它也是广泛表达的。 它由81个残基构成，与泛素相似性高达80%。 NEDD8前体需要由成熟酶切断C端，暴露出Gly76才有功能。

NEDD8 (Neural precursorcell-expressed developmentally downregulated 8) 是一种类泛素蛋白，与泛素具有约60% 的相似性和80%的同源性。 在 NEDD8活化酶 (NEDD8-Activating Enzyme，NAE)、NEDD8结合酶(UBE2M/UBC12或UBE2F)、NEDD8连接酶的级联催化下，NEDD8特异性地共价连接到底物蛋白上的过程称为 ...

2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a...

Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell extracts. Consistent with a role in cell-cycle progression, Nedd8 is expressed in proliferating cells and is itself down-regulated upon cellular differentiation.

2021年10月12日 · NEDD8 is best known for its function as a stimulator of cullin-RING ligases (CRLs) via neddylation of cullin family proteins 4, 5. It also modifies many other proteins, though the consequences of...

2018年10月22日 · Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic...