Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. [5] NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.

2024年12月25日 · NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9) is a Protein Coding gene. Diseases associated with NEDD9 include Hemochromatosis, Type 1 and Nephronophthisis. Among its related pathways is Adhesion. An important paralog of …

该蛋白是一种粘着斑蛋白，可作为支架调节信号复合物，这些信号复合物在细胞附着、迁移和侵袭以及细胞凋亡和细胞周期中很重要。 据报道，这种蛋白质在癌症转移中也有作用。 可变剪接导致多个转录本变体。 [RefSeq 提供，2012 年 8 月] The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways.

The expression of Nedd9 was upregulated in gastric cancer, high expression of Nedd9 significantly correlated with cancer progression and poor prognosis in gastric cancer. Knockdown of the NEDD9 gene results in suppression of lung adenocarcinoma cell proliferation, migration, invasion and cell growth in vitro and in vivo

2018年5月18日 · Little is known about the role of NEDD9 in ovarian carcinoma (OC), but available data suggest elevated mRNA and protein expression in advanced stage high-grade cancers. We used a transgenic...

2022年4月11日 · The NEDD9 scaffolding protein is upregulated in many advanced tumors, with increased NEDD9 promoting the activity of SRC and other effectors that promote invasion and metastasis.

神经前体细胞表达下调蛋白9（nedd9）是一种细胞骨架蛋白分子，在许多肿瘤中通过参与细 胞信号传导，包括连接一些可以直接促进肿瘤转移的分子，起到类似一个路由器的作用，进而参与肿瘤的发生和发展。

2021年10月21日 · 在癌细胞系中，缺氧会增加 nedd9的缺氧诱导因子 1α 依赖性转录调节，nedd9 是一种支架蛋白，可控制参与转移的众多蛋白质-蛋白质相互作用。 反过来，转移与异常的血小板-内皮粘附相关，从而表明 NEDD9 可能在促血栓形成病理表型的发病机制中未被识别。

2013年11月19日 · nedd9 是一种有着多个结构域的脚手架蛋白，可通过其不同结构域与不同的底物分子相互作用，参与调控细胞黏附、迁移和浸润行为，因而在肿瘤转移中扮演着重要角色。

2021年4月10日 · 2021年3月26日，呼吸领域权威期刊Am J Respir Crit Care Med（美国呼吸与危重症杂志,IF 17.452）在线发表了题为“NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-endothelial Cell Interaction in Pulmonary Hypertension”的社论（Editorial）。 总结了近期的研究进展，系统讨论了低氧上调肺血管内皮细胞NEDD9与介导血小板活化的可能分子机制，内皮细胞NEDD9的高表达通过介导血小板/内皮细胞粘附程度的增加促进肺血管血栓栓塞的形成和 …