Nef (Negative Regulatory Factor) is a small 27-35 kDa myristoylated protein encoded by primate lentiviruses. These include Human Immunodeficiency Viruses (HIV-1 and HIV-2) and Simian …

2025年1月30日 · HIV-1 Nef uniquely also acts through the serine-threonine kinase Pak2 to abate activation-induced cell death and promote survival of CAR T cells in vivo. Thus, virus-like …

2020年10月30日 · The HIV-1 accessory protein Nef is essential for viral pathogenesis, making it a promising target for antiretroviral drug discovery. Nef enhances viral replication and promotes …

The Nef auxiliary protein is expressed uniquely by primate lentiviruses and plays an important role in virus replication in vivo and in the onset of AIDS. Among its several activities Nef enhances …

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell …

Here we describe the development of proteolysis targeting chimeras (PROTACs) for the targeted degradation of Nef. Nef-binding compounds, based on an existing hydroxypyrazole core, were …

Nef是一种对HIV病毒的毒性及其引发艾滋病的能力至关重要的蛋白质，它潜在的“致命弱点”的发现为开发新型抗艾滋病药物铺平了道路。 研究人员已经成功地证明了可以将这种蛋白质与另一 …

2012年12月10日 · Nef, an accessory protein of the Human Immunodeficiency Virus type 1 (HIV-1), is dispensable for viral replication in cell culture, but promotes virus replication and …

2018年1月16日 · 现将 HIV-1Nef 蛋白功能及其增强病毒感染性分子机理的最新研究进展综述如下。1 Nef基因及蛋白结构nef 基因存在于 HIV-1、HIV-2 和 SIV 基因组中，高度保守，并与基因组末 …

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed …