2017年7月14日 · NF-κB is a central mediator of the priming signal of NLRP3 inflammasome activation and acts by inducing the transcriptional expression of NLRP3 and pro-IL-1β in response to various PRR ligands ...

核因子κB（nuclear factor kappa-B，NF-κB）蛋白最早由David Baltimore发现，该蛋白家族可以选择性的结合在B细胞κ-轻链增强子上调控许多基因的表达。 在几乎所有的动物细胞中都能发现NF-κB，它们参与细胞对外界刺激的响应，如细胞因子、辐射、重金属、病毒等。 在细胞的炎症反应、免疫应答等过程中NF-κB起到关键性作用。

2024年3月4日 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the...

NF-kB分子的N端含Rel同源域，参与其和DNA结合、参与二聚体化，能被NF-kB抑制物（TeB）结合、抑制；NF-kB分子内还有核输出域、核定位域、转位活性域等，C端有反式转录激活域。

NF-kB在细胞因子诱导的基因表达中起关键性的调控作用，它调控的基因编码急性期反应蛋白、细胞因子、细胞粘附分子、免疫调节分子、病毒瘤基因、生长因子、转录和生长调控因子等。

2020年9月21日 · Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers, and NF-κB has been long proposed as the potential target for therapy of...

活性 NF-κB/Rel 复合体进一步由翻译后修饰（磷酸化、乙酰化、糖基化）作用激活，并转运入胞核，在核内单独或联合其他转录因子，包括 AP-1、Ets 和 Stat，并共同诱导靶标基因表达。

NF-κB signal pathway may be involved in coagulation regulation in sepsis-induced ALI. The purpose of this study was to testify the hypothesis that NF-κB p65 (p65) knock-down would improve the abnormalities of coagulation and fibrinolysis mediated by lipopolysaccharide (LPS) stimulation in AECII.

2022年10月20日 · 转录因子 (tf) ap-1 和 nf-kb 在几种促炎细胞因子和相关蛋白的调节中起着关键作用，因此与许多免疫炎症和增殖性疾病有关。 最近，已经做了大量工作来阐明参与 NF-KB 和 AP-I 激活的调节途径。

NF-kB is a key TF that links inflammation to cancer. It has been shown to be involved in tumorigenesis in breast cancer and resistance to endocrine therapy. NF-kB plays an essential role in the management of inflammation, proliferation, and survival of cell lines (Lin et al. 2022; Cheng et al. 2023; Koerner et al. 2023; Que et al. 2023). As a ...