Targeted mutation assessment of 81 genes in 1021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, …

2019年5月26日 · Recurrent mutations in the Neurofibromin 1 (NF1) gene are reported in 1-5 % of AML patients; however, there are limited data regarding its prognostic implications. Here, we …

2022年11月15日 · NF1 mutations were found in about 5% of AML patients and may carry a worse prognosis. In this IRB-approved retrospective case-control study, we analyzed specific clinical …

In this letter, we present a novel case of AML with NF1 mutation that achieved a durable SR in the setting of GI septicemia. We review the entire body of literature on SR-AML, and analyze the …

2010年8月8日 · In this study, we provide a detailed analysis of NF1 aberrations in a large cohort of AML and have identified NF1 null AML blasts and NF1 null CD34+/CD38− cells to be …

2017年12月8日 · We detected a total of 59 NF1 mutations in 52 pts, for an overall frequency of 5.1% (5.2% in younger and 4.8% in older AML pts), which suggests NF1 belongs to the 20 …

2013年2月6日 · NF1 was initially identified in neurofibromatosis type 1 (NF1), an autosomal genetic disorder caused by heterozygous germline mutations or microdeletions affecting the …

2018年10月1日 · Eisfeld and colleagues [1] recently described recurrent mutations in NF1 in patients with acute myeloid leukemia (AML), with a higher frequency than seen in previous …

2010年8月15日 · Primary AML blasts without functional NF1, unlike blasts with functional NF1, displayed sensitivity to rapamycin-induced apoptosis, thus identifying a dependence on …

2010年8月11日 · NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes …