2024年6月15日 · In this review, we consolidate the current knowledge on NF2 and examine the potential connection between cancer metabolism and tumor immunity in merlin-deficient malignancies. This review may...

2001年10月15日 · NF2 mutations occurred significantly more often in sporadic atypical and anaplastic than in radiation-induced meningiomas (p < 0.02). In addition, all meningiomas were examined for mutations in the PTEN, TP53, HRAS, KRAS and NRAS genes.

We aimed to evaluate whether dual NF2/PTEN mutations comprise a more aggressive meningioma phenotype compared to tumors with only NF2 mutations. Identifying this high-risk genetic profile could allow for preventative and individualized treatment of …

Combined NF2/PTEN mutations as predictors of meningioma aggressiveness. aggressive meningioma phenotype compared to tumors with only mutations. Identifying. this high-risk genetic profile could allow for preventative and individualized treatment of these aggressive meningiomas.

qPCR表明 PTEN 敲除细胞 ARID1B 的mRNA表达水平显著降低，而在 PTEN 敲除细胞中进一步敲低 ARID1A 显著抑制细胞生长。 这些表型在PTEN缺失的乳腺癌MDA-MB-468和前列腺癌PC-3细胞系中也能体现。

高级别/进展性脑膜瘤可分为不同基因组亚型。 NF2突变相关型，占50%，与男性有关；包括CDKN2A/B、ARID1A、PTEN和KDM6A突变。 NF2不确定型占10%，以TERTp或TP53突变为特征，与性别无关。

2014年12月20日 · Rescue experiments in PTEN-deficient cells and xerographs in athymic mice indicated that loss of PTEN leads to increased NRF2 signature which provides a proliferating …

We observed a combined downregulation of PTEN signaling and an upregulation of mTOR signaling in progressive NF2-associated VS after irradiation. Immunostainings with mTOR and PTEN antibodies confirmed the respective molecular alterations.

NF2 mutations occurred significantly more often in sporadic atypical and anaplastic than in radiation-induced meningiomas ( p < 0.02). In addition, all meningiomas were examined for mutations in the PTEN, TP53, HRAS, KRAS and NRAS genes. Two mutations in the TP53 gene in a sporadic and a radiation-induced tumor were detected.

Previous observations demonstrated that the neurofibromatosis type 2 gene (NF2) plays an important role in the pathogenesis of the transitional, fibroblastic and malignant variants of human meningiomas. No specific genes have been associated with the pathogenesis of meningothelial meningiomas and wi …