
NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity …
2015年11月30日 · Here we identify the transcription factor NFATc4 as a functional link connecting inflammation-induced EGFR signaling to acinar metaplasia and show that induction of Sox9 in response to EGFR activation requires NFATc4-dependent transcriptional activation of …
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription …
Our findings identify an EGFR-NFATc1-Sox9 signaling cascade as a critical mediator of inflammation-induced PDAC initiation and suggest that disruption of this pathway may offer a novel chemopreventive target for high-risk pancreatitis patients. Keywords: signal transduction, mouse model, transcriptional regulation, ChIP, NFATc1, EGFR.
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 …
2014年5月13日 · Mechanistically, Ca (2+) influx via Cav3.2 activates the calcineurin/nuclear factor of the activated T-cell (NFAT) signaling pathway, and a previously unidentified NFAT binding site is identified within the mouse Sox9 promoter using a …
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 …
We identified an NFAT binding motif (TTTCC) in the mouse Sox9 promoter that was required for Ca v 3.2-dependent Sox9 regulation on Luc reporter assay. In addition, NFAT directly bound to the identified sequence on gel shift, supershift, and ChIP assays.
WNT5A-Ca2+-CaN-NFAT signalling plays a permissive role during …
2021年1月1日 · Sox9 in situ hybridization after 24 h of WNT5A or CaN inhibitor or NFAT inhibitor bead implantation followed by 1 h or 4 h of TGFβ treatment. Experimental design showing initial WNT5A, CaN or NFAT inhibitors or control vehicle bead implantation (time 0) in the interdigit.
WNT5A Regulates Chondrocyte Differentiation through …
Mechanistically, Wnt5a acts to increase chondrocyte differentiation at an early stage through calmodulin kinase /NFAT-dependent induction of Sox9. Conversely, Wnt5a represses chondrocyte hypertrophy via NF-κB-dependent inhibition of Runx2 expression.
NFATc1 Links EGFR Signaling to Induction of Sox9 ... - ScienceDirect
2015年5月1日 · Induction of EGFR signaling and its effects on the expression of Nuclear factor of activated T cells c1 (NFATc1) or SOX9 were investigated by quantitative reverse-transcription polymerase chain reaction, immunoblot, and immunohistochemical analyses of mouse and human tissues and acinar cell explants.
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription …
Induction of EGFR signaling and its effects on the expression of Nuclear factor of activated T cells c1 (NFATc1) or SOX9 were investigated by quantitative reverse-transcription polymerase chain reaction, immunoblot, and immunohistochemical analyses of mouse and human tissues and acinar cell explants.
group-Box gene 9 (Sox9), one of the earliest markers of committed chondrogenic cells, is reduced in Ca v3.2 −/ tracheas. Mechanistically, Ca2+ influx via Ca v3.2 activates the calcineurin/nuclear factor of the activated T-cell (NFAT) signaling pathway, and a previously uniden-tified NFAT binding site is identified within the mouse Sox9 pro-
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for …
In this study, we first demonstrated that RCAN1.4 is positively associated with disc degeneration and that hypoxia-induced downregulation of RCAN1.4 activated the calcineurin/NFAT signaling pathway to facilitate SOX9 and MMP13 expression. Furthermore, NFATc1 could directly bind the promotor regions of SOX9 and MMP13.
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