NFAT and NF-κB dynamically co-regulate TCR and CAR signaling …
2023年7月25日 · Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor κB (NF-κB), integrate …
T 细胞受体信号转导 | Cell Signaling Technology
T 细胞受体 (TCR) 激活可促进许多信号转导级联反应，通过调控细胞因子产物、细胞生存、增殖和分化来最终决定细胞命运。 TCR 激活的早期事件是由淋巴细胞蛋白质酪氨酸激酶 (Lck)，对 …
一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能 - 知乎
活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快 …
Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor B (NF- B), inte- grate through a …
A Jurkat 76 based triple parameter reporter system to evaluate TCR ...
This study is the first to present an antigen specific reporter system for the evaluation of TCR signaling via NF-κB, NFAT and AP-1 using the Jurkat 76 T cell line. The triple parameter …
NFAT proteins: key regulators of T-cell development and function
2005年6月1日 · In T cells, NFAT proteins are activated following T-cell receptor (TCR) ligation. Increases in calcium that are induced by TCR engagement activate calcineurin, which causes …
NFAT 和 NF-κB 动态共同调节人类 T 细胞中的 TCR 和 CAR 信号反 …
在这里，我们展示了 T 细胞信号传导中的两个关键途径，即活化 T 细胞的钙/核因子 (NFAT) 和蛋白激酶 C (PKC)/核因子 κB (NF-κB)，通过动态和组合策略进行整合，以精细-调整T细胞反应基 …
Hierarchy of signaling thresholds downstream of the T cell ... - PNAS
2021年8月27日 · Our results provide evidence for a hierarchy of signaling thresholds for pathways downstream of the TCR and ITK. NFAT, MAPK, and NF-κB signaling all exhibit varying …
Coupled feedback regulation of nuclear factor of activated T-cells ...
2019年7月23日 · Model simulation and analysis show that amplified activation of the transcriptional factor NFAT in response to repeated TCR stimulations, a phenomenon central …
NFAT and NF-κB dynamically co-regulate TCR and CAR
2023年7月25日 · Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor κB (NF-κB), integrate …