2024年12月25日 · NFATC2 (Nuclear Factor Of Activated T Cells 2) is a Protein Coding gene. Diseases associated with NFATC2 include Joint Contractures, Osteochondromas, And B-Cell Lymphoma and Soft Tissue Sarcoma. Among its related pathways are Activation of cAMP-Dependent PKA and BAFF in B-Cell Signaling.

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene. [5] This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR).

活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类 转录因子 家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速诱导其表达的转录因子而被发现。 NFAT在多种动物组织和细胞中广泛表达，是细胞内多条 信号转导通路 的关键调节点，在免疫系统、神经系统发育、轴突生长以及神经系统疾病中也发挥着重要作用。 NFAT蛋白的基本结构.

Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target; NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ ALDH1A1 axis in lung adenocarcinoma.

2005年6月1日 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and NFAT4 might also control thymocyte...

该基因是活化 T 细胞核因子 (NFAT) 家族的成员。 该基因的产物是具有 REL 同源区 (RHR) 和 NFAT 同源区 (NHR) 的 DNA 结合蛋白。 这种蛋白质存在于胞质溶胶中，仅在 T 细胞受体 (TCR) 刺激后转移到细胞核，在那里它成为活化 T 细胞转录复合物的核因子的成员。 该复合物在免疫反应期间诱导基因转录中起着核心作用。 编码不同亚型的替代转录剪接变体已经被表征。 [RefSeq 提供，2012 年 4 月] This gene is a member of the nuclear factor of activated T cells (NFAT) family.

2022年6月30日 · Dapl1 controls activation of NFATc2, a transcription factor required for the effector function of CD8 + T cells. Although NFATc2 mediates induction of the immune checkpoint receptor Tim3,...

2025年2月8日 · Nfatc2 plays an essential role in controlling IL-13 and TNF-alpha expression in murine mast cells. The accumulation of NFATc1 and NFATc2 in memory CD4+ T cells represents a previously uncharacterized regulatory mechanism for the induction of early gene expression after antigen stimulation.

Here we show that the calcineurin/nuclear factor of activated T cells c2 (NFATc2) pathway has an antiapoptotic role in melanoma cells. Expression of NFATc2 was constitutive in vitro and in vivo in human melanoma, and cyclosporin A (CsA) treatment of melanoma cells led …

NFATC2（Nuclear Factor of Activated T cells 2）是一种重要的转录因子，参与调控T细胞的激活和免疫反应过程。在细胞内，NFATC2被磷酸化后进入细胞核，结合靶基因的启动子区域，调节基因的转录，从而影响细胞功能。目录号 PA1000-8680NFATC2是由NFAT家族的