High-throughput sequencing identifies STAT3 as the DNA …
To determine whether RELA and p53 co-exist in a single molecular complex, we first performed co-immunoprecipitation assays and found an interaction between endogenous RELA and p53 …
P53 vs NF-κB: the role of nuclear factor-kappa B in the ... - PubMed
The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, …
An MDM2 inhibitor achieves synergistic cytotoxic effects with ...
2021年7月2日 · We investigated a role of p53 in cytotoxicity induced by p53-activating replication-competent Ad and demonstrated that increase of endogenous p53 with MDM2 inhibitors …
p53 modulates kinase inhibitor resistance and lineage ... - Nature
2024年3月13日 · Here we demonstrate a novel mechanism of therapy resistance whereby p53 alters MET stability, localization, and downstream signaling leading to kinome reprogramming …
NFIB overexpression cooperates with Rb/p53 deletion to …
2016年9月6日 · Suppression of Nfib expression in cell lines derived from the doxycycline-inducible Rb/p53/TET-Nfib model led to increased apoptosis and suppression of proliferation. …
P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation …
p53 is well known to play a fundamental role in mediating DNA Damage Response (DDR), promoting DNA repair or eventually cell cycle arrest, senescence and apoptosis . However, …
Role of NF-κB in p53-mediated programmed cell death - Nature
2000年4月20日 · Here we show that induction of p53 causes an activation of NF-κB that correlates with the ability of p53 to induce apoptosis. Inhibition or loss of NF-κB activity …
TNF-NF-κB-p53 axis restricts - Cell Press
2024年6月11日 · Transient TNF-α inhibition overcomes a p53-dependent program that restricts the survival of grafted dopamine neurons and offers a clinically relevant strategy to enhance …
Nuclear factor I revealed as family of promoter binding transcription ...
2011年4月7日 · We found that NFI/CTF family members preferentially bind their DNA target sites when they are located around transcription start sites when compared to control datasets …
An MDM2 inhibitor achieves synergistic cytotoxic effects with ...
2021年7月2日 · We investigated a role of p53 elevation by MDM2 inhibitors, nutlin-3a and RG7112, in cytotoxicity of replication-competent adenoviruses (Ad) lacking the p53-binding …