To determine whether RELA and p53 co-exist in a single molecular complex, we first performed co-immunoprecipitation assays and found an interaction between endogenous RELA and p53 proteins that was disrupted by NFI (Figure 3c). The p53-RELA interaction was direct and dependent on the carboxy-terminal transactivation domain of RELA because a ...

The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF …

2021年7月2日 · We investigated a role of p53 in cytotoxicity induced by p53-activating replication-competent Ad and demonstrated that increase of endogenous p53 with MDM2 inhibitors augmented Ad-induced DNA damage responses and promoted the viral replications through augmented NFI expression.

2024年3月13日 · Here we demonstrate a novel mechanism of therapy resistance whereby p53 alters MET stability, localization, and downstream signaling leading to kinome reprogramming and lineage plasticity.

2016年9月6日 · Suppression of Nfib expression in cell lines derived from the doxycycline-inducible Rb/p53/TET-Nfib model led to increased apoptosis and suppression of proliferation. Transcriptional analysis revealed that Nfib regulates the expression of genes related to axon guidance, focal adhesion and extracellular matrix-receptor interactions.

p53 is well known to play a fundamental role in mediating DNA Damage Response (DDR), promoting DNA repair or eventually cell cycle arrest, senescence and apoptosis . However, recent evidences suggest a strong interconnection between p53 and NF-κB pathways in mediating the response to DNA breaks.

2000年4月20日 · Here we show that induction of p53 causes an activation of NF-κB that correlates with the ability of p53 to induce apoptosis. Inhibition or loss of NF-κB activity abrogated p53-induced...

2024年6月11日 · Transient TNF-α inhibition overcomes a p53-dependent program that restricts the survival of grafted dopamine neurons and offers a clinically relevant strategy to enhance survival and promote functional dopamine neuronal engraftment in cell-based therapies for Parkinson’s disease.

2011年4月7日 · We found that NFI/CTF family members preferentially bind their DNA target sites when they are located around transcription start sites when compared to control datasets generated from the random subsampling of the complete set of NFI binding sites.

2021年7月2日 · We investigated a role of p53 elevation by MDM2 inhibitors, nutlin-3a and RG7112, in cytotoxicity of replication-competent adenoviruses (Ad) lacking the p53-binding E1B55kDa gene (Ad-delE1B).