2024年12月25日 · NFIB (Nuclear Factor I B) is a Protein Coding gene. Diseases associated with NFIB include Macrocephaly, Acquired, With Impaired Intellectual Development and Adenoid Cystic Carcinoma. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene expression (Transcription).

This gene is essential in embryonic development and it works together with its gene complex to initiate tissue differentiation in the fetus. NFIB has the highest concentrations in the lung, skeletal muscle and heart but is also found in the areas of the developing liver, kidneys and brain.

2017年8月1日 · Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer.

2023年8月21日 · Here we report that NFIB, a member of Nuclear Factor I (NFI) family that was initially purified in host cells to promote adenoviral DNA replication but has since mainly been...

2017年4月8日 · Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer.

2025年1月4日 · HIV-1 induced nuclear factor I-B (NF-IB) expression negatively regulates HIV-1 replication through interaction with the long terminal repeat region. Vemula SV, et al. Viruses, 2015 Feb 5. PMID 25664610, Free PMC Article. Genetic Variant of NFIB is Associated With the Metastasis of Osteosarcoma in Chinese Population.

2019年1月22日 · NFIB3 is a truncated 188-amino acid protein, translated from a 1.8-kb message, that contains only the N-terminal DNA-binding domain. Northern blot analysis detected the 1.8-kb NFIB3 message in HeLa cells and fibroblasts, as well as in several human tissue samples.

This gene has 22 transcripts (splice variants), 213 orthologues, 3 paralogues and is associated with 78 phenotypes. Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues.

Gene ID: 4781, updated on 8-Feb-2025. Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development and regulation of DNA-templated transcription.

Human Gene NFIB (ENST00000380953.6) from GENCODE V44 Description: Homo sapiens nuclear factor I B (NFIB), transcript variant 12, mRNA. (from RefSeq NM_001369465)

Title: Nfib promotes chondrocyte proliferation and inhibits differentiation by mildly regulating Sox9 and its downstream genes. NFIA and NFIB function as tumour suppressors in high-grade glioma in mice.

Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer.

2020年5月11日 · Through single-cell transcriptomics, ATAC-Seq and ChIP-Seq profiling, we expose a key role for NFIB and NFIX in governing super-enhancer maintenance of the key hair follicle SC-specific TF genes....

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

NFIB was found to bind to a transcriptional activator containing an ASD-associated intronic haplotype in the EN2 gene (Choi et al., 2012). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2.

Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits. The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in …

The MYB-NFIB gene fusion is the main genomic hallmark and a potential therapeutic target. Methods: Oncogenic signaling pathways were studied in cultured cells and/or tumors from 15 ACC patients. Phospho-receptor tyrosine kinase (RTK) …

Nfib gene targeting and confirmation of Nfib null allele. We constructed a replacement-type targeting vector by replacing the most 3′ 523 bp of exon 2 and the first 177 bp of intron 2 with a translational-fusion β-Gal reporter gene and a neomycin resistance gene (lacZ and Neo, respectively, in Fig. 1A). Since exon 2 encodes both the DNA ...

2025年2月8日 · Nfib promotes pro-metastatic neuronal gene expression programs and drives the metastatic ability of small cell lung cancer cells. Loss of Nfib expression resulted in prostatic hyperplasia. NFIB knockdown studies demonstrated that loss of NFIB drives increased AR expression and superinduction of a subset of AR target genes.

Title: Nfib promotes chondrocyte proliferation and inhibits differentiation by mildly regulating Sox9 and its downstream genes. NFIA and NFIB function as tumour suppressors in high-grade glioma in mice.