Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described.

2018年9月27日 · 多项研究表明，更下游的靶点， TRPV1（Transient Receptor Potential Vanilloid 1) 作为非选择性阳离子通道在NGF/TRKA介导的伤害性痛感信号传导中起关键作用。TRPV1 最初作为辣椒素受体被发现。

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis ...

神经生长因子（nerve growth factor，NGF）能促进中枢和外周神经元的生长、发育、分化、成熟，维持神经系统的正常功能，加快神经系统损伤后的修复。 NGF广泛分布于机体各组织器官中（包括脑），在靶组织中的浓度与交感神经和感觉神经在靶区分支的密度和mRNA的 ...

2024年12月25日 · NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Hereditary Sensory Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling.

2018年12月6日 · NGF-1 efficiently colonizes the mouse gut and is genetically tractable. The genome sequence reported here facilitates genetic engineering and research in mouse models of healthy and diseased intestine. The genome of the murine commensal strain Escherichia coli NGF-1 contains a 5.03-Mbp chromosome and plasmids of 40.2 kbp and 8.56 kbp.

2018年12月6日 · NGF-1 efficiently colonizes the mouse gut and is genetically tractable. The genome sequence reported here facilitates genetic engineering and research in mouse models of healthy and diseased intestine. The gut microbiome plays a key role in health and disease (1).

2017年1月23日 · The acknowledged prototypical example and best-characterized neurotrophin is nerve growth factor (NGF). 2 It acts on sympathetic and neural crest-derived sensory neurons, and is also present in the central nervous system (CNS), where it serves a trophic function in the development and maintenance of basal forebrain cholinergic neurons. 3 NGF ...

Alignment of Neurospora NGF-1 (NcNGF1) with homologues from S. cerevisiae (ScGcn5), M. grisea (MgGCN5), and G. zeae (GzGCN5). Bold letters indicate identity among proteins. Mutations resulting in...

2021年8月28日 · NGF was the first molecule of the “neurotrophin family” to be identified (Franco et al. 2020): brain-derived neurotrophic factor (BDNF) was discovered a few years later, with neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) subsequently included in …