Nerve growth factor - Wikipedia
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is …
Nerve Growth Factor Signaling and Its Contribution to Pain
2020年5月26日 · Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation, and survival of sympathetic and sensory afferent neurons during development. …
Mechanism and therapeutic effectiveness of nerve growth factor …
In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor …
神经生长因子（NGF）：一种关键的神经细胞生长调理因子
2024年4月23日 · 神经生长因子（NGF）是神经营养因子家族中的核心成员，其发现和研究始于上世纪中叶，由意大利科学家Levi-Montalcini等人率先报道。 NGF的发现，不仅为神经科学领域 …
Tanezumab: Therapy targeting nerve growth factor in pain ... - PubMed
Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin …
诺奖32周年 || 神经生长因子发现及成药记 （镇痛-抗癌-神奇眼药 …
2018年9月27日 · ngf/trka通路一方面直接诱导trpv1的通道致敏和减小其通道打开的阈值，另一方面，ngf还可以调控信号转录，增加trpv1的表达和跨膜，进一步降低伤害感受神经元动作电位产 …
The evolution of nerve growth factor inhibition in clinical medicine
2020年11月20日 · Antibodies that inhibit the function of NGF and small molecule inhibitors of NGF receptors have been developed and tested in clinical studies to evaluate the efficacy of …
疼痛管理领域的重要研发方向——全人源神经生长因子（NGF）抗 …
2024年1月19日 · STSA-1001 注射液是一种重组抗 NGF 的全人源 IgG1 单克隆抗体注射液。 该抗体可以有效阻断 NGF 与其受体的结合，从而在疼痛疾病中有效抑制 NGF 信号通路，减少因 …
Mechanism of Action - OXERVATE® (cenegermin-bkbj)
Nerve growth factor (NGF) is an endogenous protein involved in the differentiation and maintenance of neurons, which acts through specific high-affinity (ie, TrkA) and low-affinity (ie, …
Nerve Growth Factor-β (Beta-NGF) (神经生长因子) - MCE
Nerve Growth Factor-β (Beta-NGF; NGF) is a basic protein of 118 amino acids which acts are a trophic factor for sensory and sympathetic neurons of the peripheral nervous system, and on …