2022年3月18日 · Single-cell transcriptomics identified mesenchymal subpopulations with potential roles in cell migration and immune response, altered in the context of p75 deletion. Together, these results identify the role of p75 signaling pathway in coordinating skeletal cell migration during early bone repair.

2004年5月7日 · Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 Å crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75.

2024年5月17日 · However, p75 NTR can also bind mature forms of neurotrophins (such as NGF and BDNF) and can act as a tropomyosin receptor kinase (Trk) co-receptor, thereby promoting cell survival and synaptic...

2004年5月7日 · NGF has two potential sites for receptor binding, but only one is used, resulting in an asymmetric NGF:p75 structure. This unusual structure has many implications. It is well established that all neurotrophins can bind to p75.

2015年9月15日 · In the presence of TrkA receptor, p75 NTR facilitates high affinity binding of NGF and activation of cell survival pathways, while, in the absence of TrkA receptor, p75 NTR induces cell death...

2016年1月15日 · Nerve growth factor (NGF) is critical for the proliferation, differentiation, and survival of neurons through its binding to the p75(NTR) and TrkA receptors. Dysregulation of NGF has been implicated in several pathologies, including neurodegeneration (i.e., Parkinson's and Alzheimer's diseases) and …

2019年10月1日 · NGF effects are mediated by the specific expression of the NGF neurotrophic tropomyosin-receptor kinase A (TrkA) and p75 neurotrophin receptor (p75 NTR). Using NIH/3T3 fibroblast cell lines, we examined the induction of myofibroblast differentiation stimulated by NGF. Our findings showed that p75 NTR was in

2007年1月4日 · Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a “high-affinity” NGF binding site through formation of a ternary TrkA/NGF/p75 complex.

2008年7月2日 · NGF, brain-derived neurotrophic factor (BDNF) and NT-3 are members of neurotrophin family, which engage two types of single-transmembrane cell-surface receptor Trks and p75 NTR to perform a...

Nerve growth factor (NGF) signaling plays a key role in neuronal development, function, survival, and growth. 1 NGF signals by binding two types of membrane receptors: tropomyosin-related kinase A (TrkA) and p75 neurotrophin receptor (p75), a member of the tumor necrosis factor superfamily. 1,2 Both receptors can function independently by ...