Following the discovery of the neurotrophin-binding Trk receptors with kinase activity, the lack of obvious catalytic domains in p75 ICD relegated p75 to be considered an adaptor protein, …

Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of …

2004年5月7日 · Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 Å …

2000年8月1日 · Nerve growth factor (NGF) binds to two neurotrophin receptors: p75 (NTR) and p140 (Trk) (TrkA). Both receptors dimerize in response to NGF binding. TrkA homodimers and …

2007年1月4日 · Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a “high-affinity” NGF binding site through …

2015年9月15日 · In the presence of TrkA receptor, p75 NTR facilitates high affinity binding of NGF and activation of cell survival pathways, while, in the absence of TrkA receptor, p75 NTR …

Nerve growth factor (NGF) signaling plays a key role in neuronal development, function, survival, and growth. 1 NGF signals by binding two types of membrane receptors: tropomyosin-related …

2010年1月1日 · Therapeutic antagonists of NGF signaling for the control of neuroinflammatory pain have been developed by targeting the growth factor with a high-affinity monoclonal …

2004年5月7日 · A particularly intriguing prediction of this model is that there is room for binding of Trk receptors to the NGF-p75 complex (see the figure). This mechanism had been proposed …

2020年9月11日 · Neurotrophins bind to two distinct types of receptors including p75 neurotrophin receptor (p75NTR) with a lower affinity, as well as to the tropomyosin receptor kinases (Trk) …