2017年5月30日 · A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleophiles to form C–N bonds through the utilization of N-heterocyclic phosphine-butane (NHP-butane) has been developed. Both aliphatic alcohols and benzyl alcohols are suitable substrates for C–N bond construction.

2024年10月3日 · Sequential regioselective C–C bond and enantioselective C–N bond formation allows rapid assembly of a wide range of value-added chiral allylic amines from readily available N-hydroxyphthalimide (NHP) esters and 1,3-dienes under mild conditions. This developed protocol further demonstrates the versatility and potency of the photoexcited Pd ...

2021年10月6日 · In this study, we synthesized a variety of ligand structures to examine structural aspects of GalNAc ligand design: ligand valency, geometry, linker chemistry, and derivatization of the GalNAc sugar.

amines (e.g. methylaniline (1a)/2,2,4,4-tetramethylpiperidine (2a)) with CO 2 and hydrosilane ([Si]H 2, [Si] ¼ Ph 2Si), catalyzed by 1,3,2-diazaphospholene ([NHP]H). Different from the generally proposed sequential mechanism for the methylation of amine with CO 2, i.e. methylation proceeds via formylation, followed

2017年9月11日 · The chemoselectivity originates from the competition between the amine and [NHP]H hydride to attack the formyloxy carbon of [Si](OCHO) 2 (the insertion product of CO 2 into [Si]H 2). When the attack of an amine (e.g.1a) wins, the transformation affords formamide (1b) but would otherwise (e.g.2a) result in an N-methylated amine (2c).

与一般提出的用CO2进行胺甲基化的顺序机制（即甲基化通过甲酰化进行，然后进一步还原甲酰胺得到N-甲基化胺）不同，该研究表征了甲酰化和甲基化之间的竞争机制。 化学选择性源于胺和 [NHP]H氢化物之间竞争攻击 [Si] (OCHO)2（CO2插入 [Si]H2的产物）的甲酰氧基碳。 当胺（例如1a）的攻击获胜时，转化产生甲酰胺（1b），否则（例如2a）会产生N-甲基化胺（2c）。 [Si]H2 或 [NHP]H 对甲酰胺的还原在动力学上是非常不利的，因此我们呼吁关注用于理解胺与 CO2 …

2017年11月1日 · The chemoselectivity originates from the competition between the amine and [NHP]H hydride to attack the formyloxy carbon of [Si](OCHO) 2 (the insertion product of CO 2 into [Si]H 2). When the attack of an amine (e.g.1a) wins, the transformation affords formamide (1b) but would otherwise (e.g.2a) result in an N-methylated amine (2c).

2021年2月2日 · The NHP esters can be generated in situ from commercially available α-amino acid derivatives and coupled directly, resulting in a straightforward one-pot catalytic enantioselective synthesis of a variety of interesting target molecules.

The chemoselectivity originates from the competition between amine and [NHP]H hydride to attack formyloxy carbon of [Si](OCHO)2 (the insertion product of CO2 into [Si]H2). When the attack of an amine (e.g. 1a) wins, the transformation affords formamide (1b) and would otherwise (e.g. 2a) result in N-methylated amine (2c).

2016年3月30日 · A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with aryl iodides is presented. In contrast to previous studies that form alkyl radicals from carboxy...