DBCO-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition …

DBCO-acid 是一种点击化学试剂，可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545)，及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。 DBCO-acid 含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。

DBCO-NHS Ester | C23H18N2O5 | CID 77078178 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

DBCO-NHS是一种用于化学合成中偶联反应的试剂。它的主要用途是进行"点击化学"反应，特别是与炔基化合物（如炔基葡萄糖）反应，形成稳定的1,2,3-三唑化合物。 DBCO-NHS的制备方法是通过在N-羟基琥珀酰亚胺（N-hydroxysuccinimide，NHS）上引入炔基，形成DBCO-NHS。

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds.

DBCO click chemistry can be run in aqueous buffer or in organic solvents depending on the property of the substrate molecules. Reagents with PEG arm will increases the compound's hydrophilicity. This DBCO-Azide method requires to activate the biomolecule #1 with DBCO reagent, and the biomolecule #2 with azide,

NHS-DBCO（N-羟基琥珀酰亚胺-二苯基环辛炔）是一种常用于生物正交反应的化学试剂，包含了N-羟基琥珀酰亚胺（NHS）和二苯基环辛炔（DBCO）基团。 该分子结合了NHS酯的活性酯特性和DBCO的生物正交化学反应能力，在生物分子标记、交联、药物递送系统以及功能化材料的制备中具有广泛应用。 生物正交反应性：DBCO基团能够与叠氮基（Azide）基团发生快速且选择性强的点击反应，而不需要催化剂（如铜）。 这种反应广泛应用于生物分子的标记、成像以及交联 …

DBCO-NHS ester is commonly used in bioconjugation. It consists of an NHS ester that reacts with primary amines on biomolecules and an alkyne group that allows for a specific reaction with molecules containing azides. This reaction is carried out through a copper-free click chemistry process called strain-promoted alkyne-azide cycloaddition.

DBCO-NHS是一种用于化学合成中偶联反应的试剂。它的主要用途是进行"点击化学"反应，特别是与炔基化合物（如炔基葡萄糖）反应，形成稳定的1,2,3-三唑化合物。 DBCO-NHS的制备方法是通过在N-羟基琥珀酰亚胺（N-hydroxysuccinimide，NHS）上引入炔基，形成DBCO-NHS。

2024年5月21日 · dbco-nhs作为药物递送系统的关键组成部分，可以通过特异性连接将药物分子与靶向分子偶联，实现药物的精确释放。 这种偶联方式不仅提高了药物的生物利用度，还增强了药物对病变组织的穿透力，为药物递送提供了途径。