2016年3月21日 · Among the 14-3-3 proteins, 14-3-3ɛ serves a crucial function in antiviral immunity by mediating the cytosol–to–mitochondrial membrane translocation of the pathogen sensor RIG-I. Here we found that...

14-3-3 proteins regulate biological processes by binding to phosphorylated serine or phosphorylated threonine motifs of cellular proteins. Among the 14-3-3 proteins, 14-3-3...

Among the 14-3-3 proteins, 14-3-3ɛ serves a crucial function in antiviral immunity by mediating the cytosol-to-mitochondrial membrane translocation of the pathogen sensor RIG-I. Here we found that the NS3 protein of dengue virus (DV) bound to 14-3-3ɛ and prevented translocation of RIG-I to the adaptor MAVS and thereby blocked antiviral signaling.

板载NI‑STC3定时和同步技术提供高级定时功能，包括独立的模拟和数字定时引擎和可重新触发的测量任务。 PCIe‑6323适用于从基本数据记录到控制和测试自动化等广泛的应用。

1999年2月1日 · Using this approach we develop reliable interatomic potentials for Al and Ni. The potentials accurately reproduce basic equilibrium properties of these metals, the elastic constants, the phonon-dispersion curves, the vacancy formation and migration energies, the stacking fault energies, and the surface energies.

Dengue is an arthropod borne viral infection that is listed as a neglected tropical disease (Wilder-Smith et al., 2019). It is one of the major health threats globally and has experienced a massive increase in incidents over the past half century. However, no …

1997年7月29日 · We have analyzed the functional domains of the Drosophila orphan receptor Ultraspiracle (usp), a homologue of the vertebrate retinoic X receptor α, as well as the ability of heterodimers between usp and the thyroid hormone receptor β (T 3 Rβ) to transactivate the human apolipoprotein A-II (apoA-II) promoter.

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Here we found that the NS3 protein of dengue virus (DV) bound to 14-3-3ɛ and prevented translocation of RIG-I to the adaptor MAVS and thereby blocked antiviral signaling. Intriguingly, a highly conserved phosphomimetic RxEP motif in NS3 was essential for the binding of 14-3-3ɛ.

2021年2月9日 · In this paper, single-step photonic curing of screen-printed nickel (Ni) electrodes is reported for sensor, interconnector and printed electronics applications.