Negative inspiratory force (NIF) is the maximum pressure that can be generate against an occluded airway and is a marker of respiratory muscle function and strength. The Negative Inspiratory Force index (NIF) measures the patient’s maximum inhalation effort after exhaling. The patient system is closed during measurement of the NIF.

Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium, which worsens the paralysis caused by cholinergic crisis, but strengthens the muscle in the case of myasthenia gravis.

MIP = Maximal Inspiratory Pressure. This is the greatest negative pressure the patient can generate, often also referred to as the NIF (Negative Inspiratory Force). It is measured asking patients to inhale as hard as they can with measurement of the negative pressure that they generate using a pressure gauge (image above).

Myasthenic crisis is a life-threatening exacerbation of myasthenia gravis that is defined as worsening of myasthenic weakness requiring intubation or noninvasive ventilation [1].

2023年6月17日 · Myasthenia gravis results from the formation of autoantibodies that bind to acetylcholine receptors on skeletal muscle. Direct reversible inhibition of acetylcholine binding to its receptor. Antibodies can lead to destruction of acetylcholine receptors via complement fixation, decreasing the number of receptors.

The National Ignition Facility (NIF) is the size of a sports stadium—three football fields could fit inside. NIF’s unique energy and power enable cutting-edge research to help keep America safe and secure, explore new frontiers of science, and lay the groundwork for a clean, sustainable source of energy.

For non-intubated patients, doses should be started lower (10-20mg) and increased by 5mg every 2-3 days; goal typically 60-80mg/day For intubated patients, higher initial doses may be tolerated

2017年2月24日 · NIF: Normal values in males are > -75 and in females are > – 50. This is patient effort dependant, and hence, a low value value doesn’t indicate respiratory muscle weakness. The threshold value is -20 to -30.

Maximal inspiratory pressure (MIP) is the most commonly used measure to evaluate inspiratory muscle strength. Normative values for MIP vary significantly among studies, which may reflect differences in participant demographics and technique of MIP measurement.

2015年3月6日 · • Negative inspiratory force (NIF) also is called negative inspiratory pressure (NIP) or sometimes maximal inspiratory pressure (MIP). The measurement of NIF is effort independent (the patient does not have to actively cooperate) and is considered the most reliable of the standard weaning criteria (SWC).

As evidenced by our study, we can reach 100% success rate by altering the NIF goal independent of the RSBI criteria. Using NIF <-30 cm H2O as criteria, we have a positive predictive value of 100% and a negative predictive value of 50%, ensuring success.

Objectives: The negative inspiratory force (NIF) has been used to help clinicians predict a patient's likelihood of successful liberation from mechanical ventilation (MV). However, the utility of the traditional threshold of ≤-30 cmH 2 O may not be appropriate for patients with chronic obstructive pulmonary disease (COPD).

2019年6月11日 · The forced vital capacity (FVC) and negative inspiratory force (NIF) are the main parameters for monitoring severity of crisis and response to treatment. An easy bedside technique to get a rough estimate of the FVC is to have the patient take a deep breath in and count aloud.

Achieving ignition—producing more fusion energy than the amount of laser energy delivered to the NIF target—provides new opportunities for stockpile stewardship applications; NIF’s recreation of extreme environments allows scientists to study the behavior of materials under weapons-relevant conditions that were previously impossible to ...

2024年7月25日 · 国家点火装置 （英语： National Ignition Facility， 缩写 作 NIF），又称 国家点燃实验设施[1]，是 美国 的一座基于 激光 的 惯性约束核聚变 （ICF）装置。 这个设施由 劳伦斯利福摩尔国家实验室 建造，位于 加州 的 利佛摩 市 37°41′25.7″N 121°42′03.8″W。 NIF意图使用激光（Laser）达成极大高温高压施加于一小粒氢燃料球上启动 核聚变反应。 NIF也是人类史上最大的ICF设施和世界上最大的激光装置 [2]，其目标是实现点火，以令其聚变燃料进入点燃状态。 …

2024年8月29日 · Myasthenia Gravis (MG) is a heterogenous neuromuscular junction (NMJ) disorder in which the body elicits an autoimmune response against postsynaptic acetylcholine receptors.

The official NIF Project definition of Scientific Breakeven was given by the NIF Project Head Ed Moses when describing the NIF goal as : “..producing more energy than the energy in the laser pulse and achieving scientific breakeven.”

NIF’s overarching mission is Stockpile Stewardship, with a goal of maintaining the safety and reliability of the U.S. nuclear deterrent without testing. NIF shots also support High Energy Density Science, Ignition Science, Discovery Science, and National Security Applications.

2011年3月16日 · The NIF will enable exploration of scientific problems in national strategic security, basic science and fusion energy. One of the early NIF goals centers on achieving laboratory-scale thermonuclear ignition and energy gain, demonstrating the feasibility of laser fusion as a viable source of clean, carbon-free energy.

2021年8月27日 · News of the breakthrough has revived hopes that the long-troubled National Ignition Facility (NIF) might yet attain its goal of producing more energy than it consumes in a sustained fusion...