N-Iodosuccinimide (NIS) is a reagent used in organic chemistry for the iodination of alkenes and as a mild oxidant. [2] NIS is the iodine analog of N-chlorosuccinimide (NCS) and N-bromosuccinimide (NBS) which are used for similar applications.

Active iodide (I −) transport in both the thyroid and some extrathyroidal tissues is mediated by the N a + /I − symporter (NIS). In the thyroid, NIS-mediated I − uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. THs are key during embryonic and postembryonic development and critical for cell metabolism at all stages of life.

NIS是一个很好的碘代试剂，能顺利地将乙烯基硅烷和乙烯基锡烷转化成相应的 乙烯基碘代物。 在温和的条件下，烯烃硼酸与 NIS 反应能够被转化成为几何构型. 不变的烯烃碘代物。 在 NIS作用下，α-炔醇或乙酰化的α-炔醇可生成相应的α-碘代烯酮产物一般具有Z-构型。 NIS与炔基容易形成碘鎓离子中间体。 如果在适当的位置存在一个亲电基团，则很容易关环形成杂环化合物。 在NIS存在下，可以在苯环上发生碘代反应。 例如：在含有对甲苯磺酸的乙腈溶液中，苯酚与NIS反应生 …

NIS是有机化学中一种重要的亲电碘代试剂，可以与烯基铝的中间体反应来制备烯基碘化合物，也可以作为一种氧化试剂，氧化并使二肤环合而制备β-内酰胺。 NIS是一个很好的碘代试剂，能顺利地将乙烯基硅烷和乙烯基锡烷转化成相应的乙烯基碘代物。 另外，在温和的条件下，烯烃硼酸与NIS反应能转化为几何构型不变的烯烃碘代物。 NIS容易分解，应该在氮气保护下低温且避光、防潮保存。 使用时应注意采取必要措施，防止吸入有刺激性气味的粉末。 （chemicalbook 小娟 …

The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), [5] is a protein that in humans is encoded by the SLC5A5 gene. [6] [7] [8] It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na +) for each iodide anion (I −) into the cell. [9]

The Na(+)/I(-) symporter (NIS) is an integral plasma membrane glycoprotein that mediates active I(-) transport into the thyroid follicular cells, the first step in thyroid hormone biosynthesis. NIS-mediated thyroidal I(-) transport from the bloodstream to the colloid is a …

Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β-emitting radioactive iodide is routinely utilized to target remnant …

A convenient radical oxidative cyclization mediated by N-iodosuccinimide (NIS) enables the synthesis of a series of dibenzopyranones from a wide scope of 2-arylbenzoic acids. The methodology offers good functional group tolerance and mild reaction conditions without the use of transition metals.

2013年9月19日 · Thyroid iodide accumulation via the sodium/iodide symporter (NIS; SLC5A5) has been the basis for the longtime use of radio-iodide in the diagnosis and treatment of thyroid cancers. NIS is also...

N-iodosuccinimide is a five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom. It is a dicarboximide and a pyrrolidinone. It is functionally related to a succinimide. Copyright © 1980, 1981-2025 John Wiley & Sons, Inc. All Rights Reserved. Copyright © 1980, 1981-2025 John Wiley & Sons, Inc. All Rights Reserved.