Viruses up-regulating/down-regulating NKp44L expression on infected cells are indicated with up and down arrows. Green arrows indicate interactions resulting in NK cell activation, while...

2022年1月27日 · NKp44 is a 44 kDa transmembrane glycoprotein characterized by a single extracellular V-type domain. The transmembrane domain contains the charged amino acid lysine and is involved in the association of NKp44 with the adaptor protein DAP12 containing an ITAM (immunoreceptor tyrosine-based activation motif) for signaling ( 4 , 7 , 8 ).

2013年10月24日 · NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand.

2004年1月15日 · NKp44 (NCR2) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. We dissected structural attributes of NKp44 to determine their contributions to receptor function.

1998年6月15日 · In this study we identified a novel 44-kD surface molecule (NKp44) that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2.

One important family of activating receptors is the natural cytotoxicity receptors (NCRs) which include NKp30, NKp44 and NKp46. The NCRs initiate tumor targeting by recognition of heparan sulfate on cancer cells. This study aims to elucidate heparan sulfate structural motifs that are important for NCR binding.

Find the NKp44 antibody that fits your needs. Choose from 1 of 14 NKp44 antibodies, which have been validated in experiments with 10 publications and 28 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications.

NKp44 enhances NK cell mediated cytolysis of virus infected cells and tumor cells. NKp44 has been shown to associate with the intracellular adaptor DAP12. The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.

NKp44 is a ~44 kDa type I transmembrane protein that belongs to the natural cytotoxicity receptor (NCR) family within the immunoglobulin superfamily. NKp44 is expressed by activated NK cells. NKp44 serves as an activating receptor that can enhance NK cell mediated lysis of target cells including tumor cells and virus-infected cells.

One important family of activating receptors is the natural cytotoxicity receptors (NCRs) which include NKp30, NKp44 and NKp46. The NCRs initiate tumor targeting by recognition of heparan sulfate on cancer cells. This study aims to elucidate heparan sulfate structural motifs that are important for NCR binding.