2022年9月27日 · NKp46 + NK cell impairment through γc deficiency is associated with increased susceptibility to filarial parasites. We infected RAG2-/-and RAG2-/-γc-/-immunodeficient and BALB/c immunocompetent mice with B. malayi infectious larvae and examined impact on NKp46 + NK cell expansion within the peritoneal infection site.

2024年8月13日 · Using high-resolution single-cell profiling of kidney immune and parenchymal cells, in combination with antibody blockade and genetic deficiency, we show that tissue-resident NKp46 + innate...

We have developed a novel, fully synthetic tumor binding and NKp46 binding NK-TICA® molecule that is capable of inducing NK cell activation in the presence of tumor. As an immunotherapeutic agent, Bicycle’s NK-TICA® molecules are positioned to engage NK cells in. NK cells (based on Chiossone et al., 2018).

We report here the generation of trifunctional natural killer (NK) cell engagers (NKCEs), targeting two activating receptors, NKp46 and CD16, on NK cells and a tumor antigen on cancer cells. Trifunctional NKCEs were more potent in vitro than clinical therapeutic antibodies targeting the same tumor antigen.

• NKp46 - an untapped target − Activating receptor constitutively expressed on NK cells − Not down-regulated in the TME like CD16 or NKG2D − Encouraging preclinical data reported (Gauthier, 2019) 17 Natural killer (NK) cells have emerged as important early drivers of the adaptive anti-tumor immune response Program hypothesis:

We have developed a novel, fully synthetic EphA2 and NKp46 binding NK-TICATM molecule that is capable of inducing NK cell activation in the presence of tumor. As an immunotherapeutic agent, Bicycle’s NK-TICATM molecules are positioned to engage NK cells in a tumor antigen dependent manner to kill and drive adaptive immunity in solid tumors.

NKp46 (lymphocyte antigen 94, LY94) is a natural cytotoxicity receptor that belongs to the immunoglobulin superfamily and is expressed by all resting or activated NK cells, but not on T cells or B cells. The NKp46 cDNA encodes a 304 amino acid type I transmembrane protein with an extracellular region

eosinophils whereby NKp46+ NK cells express markers of memory-like/ enhanced activation (increased expression of interferon gamma and Ly6C). Our data promotes a novel functional role for NKp46+ NK cells in immunoprotection against experimental primary and secondaryfilarial infection which can proceed in the absence of adaptive immune ...

2023年11月29日 · To inform nanoreagent design, a model system of planar substrates with anchored mAb is first investigated. Combining mAb that stimulates three NK cell activating receptors (αNKP46 + αNKG2D + αDNAM-1), activated NK …

2022年9月27日 · NKp46 + NK cell impairment through γc deficiency is associated with increased susceptibility to filarial parasites. We infected RAG2-/-and RAG2-/-γc-/-immunodeficient and BALB/c immunocompetent mice with B. malayi infectious larvae and examined impact on NKp46 + NK cell expansion within the peritoneal infection site.