NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. [5][6] The NLRC4 protein is highly conserved across mammalian species. It …

2024年12月25日 · NLRC4 (NLR Family CARD Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRC4 include Familial Cold Autoinflammatory Syndrome 4 and …

The NLRC4 inflammasomopathies are caused by gain-of-function mutations in the gene encoding the innate immune protein NLRC4. Mutant NLRC4 promotes spontaneous formation of the …

The current understanding of the NLRC4 inflammasome is perhaps the most comprehensive illustration of the inflammasome paradigm: trigger (e.g. cytosolic flagellin), sensor (NAIP), …

2021年11月30日 · We explored whether NLRC4 knockdown alleviated inflammatory injury following intracerebral hemorrhage (ICH). Furthermore, we investigated whether NLRC4 …

In this review we give an overview of the NAIP/NLRC4 activation mechanism as well as the described roles of this inflammasome, with a focus on in vivo infection and pathology. After …

2024年1月4日 · The NLR family caspase activation and recruitment domain-containing 4 (NLRC4) inflammasome is a critical cytosolic innate immune machine formed upon the direct sensing of …

NLRC4是NOD样受体家族中的一员，主要感受细菌的鞭毛蛋白和III型分泌系统等成分，从而引发对相关病原菌入侵的免疫应答。 NLRC4在正常情况下通过自抑制作用处于静息状态；当病原菌 …

2011年9月14日 · The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod …

In this review article, we provide an updated overview of NLRC4 inflammasomes, describing their composition, activation mechanisms and roles in both microbial infections and other disease …