The Emerging Role of NMDA Antagonists in Pain Management - U.S. Pharmacist
May 18, 2011 · In a double-blind, randomized, controlled, crossover trial conducted in 18 patients who did not respond to traditional analgesic regimens for their chronic neuropathic pain, 10 mg twice daily oral methadone showed statistically significant pain relief in maximum pain intensity (P = .013), average pain intensity (P = .020), and relief of pain (P ...
Expanding Role of NMDA Receptor Antagonists in the Management of Pain
This narrative review provides an overview of the NMDA receptor and elaborates on the pharmacotherapeutic profile and pain management literature findings for the following NMDA receptor antagonists: ketamine, memantine, dextromethorphan, and magnesium.
NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain.
Targeting the N-Methyl-d-Aspartate Receptor for Chronic Pain …
Nov 1, 2000 · Given that CPP is a selective NMDA receptor antagonist, this study provides convincing evidence that spinal NMDA receptors may contribute to the maintenance of extraterritorial neuropathic pain in chronic pain patients.
Expanding Role of NMDA Receptor Antagonists in the Management of Pain ...
Mar 2, 2019 · NMDA receptor antagonists have garnered increasing attention over recent years as an adjunctive/alternative pain treatment modality. Ketamine is the most studied NMDA receptor antagonist used to treat pain and, as such, possesses the most clinical utility at this point in time.
The role of N-methyl-D-aspartate (NMDA) receptors in pain: a …
There is accumulating evidence to implicate the importance of N-methyl-D-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain.
NMDA Receptor Dependent Long-term Potentiation in Chronic Pain …
Aug 14, 2018 · Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of …
NMDA-Receptor Antagonists in Neuropathic Pain - ScienceDirect
Jan 1, 2000 · NMDA-receptor antagonists reduced spontaneous pain and hyperalgesia when administered in single intravenous doses (ketamine), and in patients with diabetic neuropathy when administered chronically at high oral doses (dextromethorphan). This class of drugs may offer a new and reasonably well-tolerated single therapy for chronic administration.
NMDA Receptor Antagonists in the Treatment of Pain
Nov 13, 2014 · NMDA antagonists can be efficacious in the treatment of chronic pain states, particularly neuropathic pain, as well as in the management of any non-neuropathic opioid-resistant pain due to developing opioid tolerance or opioid-induced hyperalgesia (OIH).
Update on the Neurophysiology of Pain Transmission and …
Jan 1, 2000 · Prolonged firing of C-fiber nociceptors causes release of glutamate which acts on N-methyl- d -aspartate (NMDA) receptors in the spinal cord. Activation of NMDA receptors causes the spinal cord neuron to become more responsive …