2002年6月24日 · Here we show that NPM interacts directly with the tumour suppressor p53, regulates the increase in stability and transcriptional activation of p53 after different types of …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

In the first volume, we include seven papers that focus on the function and regulation of the wild-type protein. In a highly focused study, Fahreus and colleagues (Karakostis et al., 2019) …

Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. In …

2022年11月1日 · Using genome-wide loss-of-function screens, we demonstrate the ribosome biogenesis axis as the most potent class of genes whose disruption stabilizes p53. …

2022年2月18日 · We consider non-nuclear heterologous protein complexes of p53, their structural determinants, regulatory post-translational modifications and the role in intricate p53 functions. …

结论：Ki-67和p53的表达对于鉴别水泡状胎块与流产水肿绒毛有重要价值，但对于区别完全性与部分性水泡状胎块其价值有限；而 p57蛋白在CHM和PHM的表达和分布有明显差异，可作为水 …

2019年3月1日 · In this Review, we focus on discussing the established function of p53 as a transcription factor. p53 is activated by cellular stresses including DNA damage, hypoxia, …

The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have …