Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and …

NMR is nowadays an important tool for the monitoring of chemical reactions in academic and industrial settings. Utilization of the inherent structural and quantitative information delivered via NMR spectroscopy provides detailed mechanistic insights and increased process understanding.

In-line benchtop NMR enables diversified structural and quantitative data on the chemical composition to be obtained and determination of reaction conversions, kinetics and mechanisms. This review provides an overview of the state-of-the-art of flow reactors integrating in-line monitoring with benchtop NMR spectrometers.

2024年11月15日 · Automated optimization of biocatalytic microreactors using inline NMR analysis and open-source control software enables autonomous adjustment of pump flow rates in real time to achieve target product concentrations and efficient utilization of the biocatalyst.

The Wisconsin High Pressure NMR Reactor (WiHP-NMRR) design comprises four modules: a sapphire NMR tube with titanium tube holder rated for pressures as high as 1000 psig (68 atm) and temperatures ranging from -90 to 90 °C, a gas circulation system that maintains equilibrium concentrations of dissolved gases during gas-consuming or gas ...

2024年6月29日 · In this contribution, we introduce the concept of autonomous self-optimizing flow reactors guided by in-line high-field NMR spectroscopy. We designed an autonomous experimental setup, combining an automated flow reactor with a high-field NMR spectrometer and a feedback optimization algorithm.

2023年2月20日 · In this work, magnetic resonance techniques are applied to characterize the FT reaction occurring in a pilot-scale fixed-bed reactor. The present work reports one-dimensional (1D),...

1 天前 · The 31 P NMR spectrum of the precipitation of zirconium extracted complexes is shown in Fig. 6. It can be observed that there is only one signal at − 16.31 ppm in the 31 P NMR spectrum. This indicates that only one form of phosphorus is present in the extracted complexes, that is, either DiAP or TiAP is involved in the coordination with Zr(IV).

A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimizat

2015年10月15日 · The Wisconsin High Pressure NMR Reactor (WiHP-NMRR) design comprises four modules: a sapphire NMR tube with titanium tube holder rated for pressures as high as 1000 psig (68 atm) and temperatures ranging from −90 to 90 °C, a gas circulation system that maintains equilibrium concentrations of dissolved gases during gas-consuming or gas ...