2008年1月4日 · Here we show that transforming growth factor β-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling. We found that TAK1 deletion completely abolished MDP-NOD2 signaling, activation of NF-κB and MAPKs, and subsequent induction of cytokines/chemokines in keratinocytes.

2023年12月20日 · Taking it into consideration that TLR4 is the predominant receptor for HMGB1, we applied TAK-242, an inhibitor of the TLR4 pathway, to explore potential interaction between NOD2 and TLR4. Real-time PCR confirmed significant reduction in NOD2 expression in macrophages transfected with si-NOD2.

2011年7月13日 · NOD2 (nucleotide-binding oligomerization domain 2) is a member of the NLR (NOD, leucine-rich repeat (LRR)-containing protein) family of intracellular sensors of...

NOD2 （Nucleotide-binding oligomerization domain 2）也被称为NLRC2，属于NLR家族，是革兰氏阳性和革兰氏阴性细菌的肽聚糖（PGN）衍生的细胞内 模式识别受体 （PRRs）。 NOD2由多种细胞类型表达，包括造血细胞（如T细胞、B细胞、巨噬细胞、树突状细胞和肥大细胞）和非造血细胞（如 潘氏细胞 、干细胞、杯状细胞和肠细胞），在胞浆中处于一种抑制的单体状态，配体识别时激活其构象发生变化，进而招募 丝氨酸 /苏氨酸蛋白激酶2（RIPK2）激活IKK复合物 …

2008年1月1日 · We found that TAK1 deletion completely abolished MDP-NOD2 signaling, activation of NF-κB and MAPKs and subsequent induction of cytokines/chemokines, in keratinocytes. NOD2 and its downstream effector RICK associated with and activated TAK1. TAK1-deficiency also abolished MDP-induced NOD2 expression.

2008年1月4日 · Here we show that transforming growth factor beta-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling. We found that TAK1 deletion completely abolished MDP-NOD2 signaling, activation of NF-kappaB and MAPKs, and subsequent induction of cytokines/chemokines in keratinocytes.

Our results revealed that NOD2 promotes microglial inflammation by increasing inflammatory mediators. We also showed that the TAK1-NF-κB pathway is involved in this process. In addition, NOD2 increased the expression of autophagy-related proteins and …

2020年5月1日 · Our results revealed that NOD2 promotes microglial inflammation by increasing inflammatory mediators. We also showed that the TAK1-NF-κB pathway is involved in this process. In addition, NOD2 increased the expression of autophagy-related proteins and induced autophagosome formation.

Here we show that transforming growth factor -activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling. We found that TAK1 deletion completely abolished MDP-NOD2 signaling, activation of NF- B and MAPKs, and subsequent induction of …

2004年6月11日 · In this study, we determined that mitogen-activated protein kinase kinase transforming growth factor (TGF)-β-activated kinase 1 (TAK1) interacts with Nod2 and is required for Nod2-mediated NF-κB activation. The dominant negative form of TAK1 abolished muramyl dipeptide-induced NF-κB activation in Nod2-expressing cells.