NADPH oxidase 2 (Nox2), also known as cytochrome b (558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).

升高的 CYBB，也称为 NOX2，与报告一致，即它是杀菌吞噬细胞氧化酶系统的主要成分，并在 M1-MФs 中产生 ROS。 ETC 复合物 IV 的以下细胞色素 C 氧化酶 (COX) 在 M2-MФs 中上调：COX2 (MT-CO2) 片段、COX5B、COX15、COA3（COX 组装因子 3）、OXA1L（COX 组装 1 样）和 TACO1 （COX1 的 ...

2024年12月24日 · CYBB (Cytochrome B-245 Beta Chain) is a Protein Coding gene. Diseases associated with CYBB include Immunodeficiency 34 and Granulomatous Disease, Chronic, X-Linked. Among its related pathways are Signaling by Rho GTPases and Innate Immune System.

Here, we report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4 + T cells through LC3-associated phagocytosis (LAP).

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2. CYBB-Mediated Ferroptosis Associated with Immunosuppression in Mycobacterium leprae-Infected Monocyte-Derived Macrophages. Nox2 inhibition reduces trophoblast ferroptosis in preeclampsia via the STAT3/GPX4 pathway.

Here, we report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4 T cells through LC3-associated phagocytosis (LAP).

A pairwise comparison of AML versus healthy gene expression revealed the downregulation of four members of the NOX2 complex including CYBB (coding for NOX2) in AML patients. We analyzed the expression of 941 genes related to metabolism and found 28 genes with expression correlated to CYBB.

2025年1月4日 · Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD).

NOX2, also known as gp91phox, cytochrome b -558 beta-subunit or cytochrome b -245 heavy chain, is a glycoprotein encoded by the CYBB gene (aliases, NOX2, gp91phox, CGD).

2023年8月1日 · An in vivo screen using 810 mutant mouse lines identified several components of the NOX2 complex (Cybb, Ncf1 and Cyba) as key contributors of cancer development in a model of lung colonization with the B16F10 melanoma cell line [196].