2024年12月25日 · NOX3 (NADPH Oxidase 3) is a Protein Coding gene. Diseases associated with NOX3 include Drug-Induced Hearing Loss and Phagocyte Bactericidal Dysfunction. Among its related pathways are Signaling by Rho GTPases and Apoptotic Pathways in Synovial Fibroblasts.

NADPH oxidases, such as NOX3, are plasma membrane-associated enzymes found in many cell types. They catalyze the production of superoxide by a 1-electron reduction of oxygen, using NADPH as the electron donor.[supplied by OMIM] [7]

2025年2月8日 · In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase, plays an integral role in insulin-induced p42/44 Mitogen-activated protein kinase signal transmission and VEGF-A production.

NOX from phagocytes catalyzes, via one-electron trans-membrane transfer to molecular oxygen, the production of the superoxide anion. Over the years, six human homologs of the catalytic subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and …

2023年6月23日 · NADPH oxidase 3 (NOX3) is the catalytic subunit of a superoxide-producing enzyme complex in the inner ear. Other subunits of this complex include p22phox and NOX organizer 1 (NOXO1). Both of these accessory proteins are essential for …

We show that it generates low levels of ROS in a subunit-independent manner and high levels of ROS in the presence of activator and organizer subunits. We also demonstrate that an ototoxic drug, cisplatin, markedly increases NOX3-dependent superoxide production.

2022年5月18日 · Professional phagocytes such as neutrophils (PMNs), eosinophils, monocytes, and macrophages use superoxide-generating NADPH oxidase (NOX) as part of their arsenal of antimicrobial mechanisms to...

2004年10月29日 · Our data suggest that NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs.

2014年11月1日 · In contrast, Nox1 to Nox3 are not directly calcium sensitive, although calcium is involved in the upstream mechanism of their activation. Two main elements contribute to this process: interaction with the small GTPase Rac and interaction with cytosolic activator proteins.

Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91 (phox)), the homologs are now referred to as the NOX family of NADPH oxidases.